<?xml version="1.0" ?>
<!DOCTYPE Entrezgene-Set PUBLIC "-//NLM//DTD NCBI-Entrezgene, 21st January 2005//EN" "https://www.ncbi.nlm.nih.gov/data_specs/dtd/NCBI_Entrezgene.dtd">
<Entrezgene-Set>
<Entrezgene>
  <Entrezgene_track-info>
    <Gene-track>
      <Gene-track_geneid>2</Gene-track_geneid>
      <Gene-track_status value="live">0</Gene-track_status>
      <Gene-track_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>1998</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>2</Date-std_day>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-track_create-date>
      <Gene-track_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2024</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>12</Date-std_minute>
              <Date-std_second>50</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-track_update-date>
    </Gene-track>
  </Entrezgene_track-info>
  <Entrezgene_type value="protein-coding">6</Entrezgene_type>
  <Entrezgene_source>
    <BioSource>
      <BioSource_genome value="genomic">1</BioSource_genome>
      <BioSource_origin value="natural">1</BioSource_origin>
      <BioSource_org>
        <Org-ref>
          <Org-ref_taxname>Homo sapiens</Org-ref_taxname>
          <Org-ref_common>human</Org-ref_common>
          <Org-ref_db>
            <Dbtag>
              <Dbtag_db>taxon</Dbtag_db>
              <Dbtag_tag>
                <Object-id>
                  <Object-id_id>9606</Object-id_id>
                </Object-id>
              </Dbtag_tag>
            </Dbtag>
          </Org-ref_db>
          <Org-ref_orgname>
            <OrgName>
              <OrgName_name>
                <OrgName_name_binomial>
                  <BinomialOrgName>
                    <BinomialOrgName_genus>Homo</BinomialOrgName_genus>
                    <BinomialOrgName_species>sapiens</BinomialOrgName_species>
                  </BinomialOrgName>
                </OrgName_name_binomial>
              </OrgName_name>
              <OrgName_attrib>specified</OrgName_attrib>
              <OrgName_lineage>Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</OrgName_lineage>
              <OrgName_gcode>1</OrgName_gcode>
              <OrgName_mgcode>2</OrgName_mgcode>
              <OrgName_div>PRI</OrgName_div>
            </OrgName>
          </Org-ref_orgname>
        </Org-ref>
      </BioSource_org>
      <BioSource_subtype>
        <SubSource>
          <SubSource_subtype value="chromosome">1</SubSource_subtype>
          <SubSource_name>12</SubSource_name>
        </SubSource>
      </BioSource_subtype>
    </BioSource>
  </Entrezgene_source>
  <Entrezgene_gene>
    <Gene-ref>
      <Gene-ref_locus>A2M</Gene-ref_locus>
      <Gene-ref_desc>alpha-2-macroglobulin</Gene-ref_desc>
      <Gene-ref_maploc>12p13.31</Gene-ref_maploc>
      <Gene-ref_db>
        <Dbtag>
          <Dbtag_db>HGNC</Dbtag_db>
          <Dbtag_tag>
            <Object-id>
              <Object-id_str>HGNC:7</Object-id_str>
            </Object-id>
          </Dbtag_tag>
        </Dbtag>
        <Dbtag>
          <Dbtag_db>Ensembl</Dbtag_db>
          <Dbtag_tag>
            <Object-id>
              <Object-id_str>ENSG00000175899</Object-id_str>
            </Object-id>
          </Dbtag_tag>
        </Dbtag>
        <Dbtag>
          <Dbtag_db>MIM</Dbtag_db>
          <Dbtag_tag>
            <Object-id>
              <Object-id_id>103950</Object-id_id>
            </Object-id>
          </Dbtag_tag>
        </Dbtag>
        <Dbtag>
          <Dbtag_db>AllianceGenome</Dbtag_db>
          <Dbtag_tag>
            <Object-id>
              <Object-id_str>HGNC:7</Object-id_str>
            </Object-id>
          </Dbtag_tag>
        </Dbtag>
      </Gene-ref_db>
      <Gene-ref_syn>
        <Gene-ref_syn_E>A2MD</Gene-ref_syn_E>
        <Gene-ref_syn_E>CPAMD5</Gene-ref_syn_E>
        <Gene-ref_syn_E>FWP007</Gene-ref_syn_E>
        <Gene-ref_syn_E>S863-7</Gene-ref_syn_E>
      </Gene-ref_syn>
      <Gene-ref_formal-name>
        <Gene-nomenclature>
          <Gene-nomenclature_status value="official"/>
          <Gene-nomenclature_symbol>A2M</Gene-nomenclature_symbol>
          <Gene-nomenclature_name>alpha-2-macroglobulin</Gene-nomenclature_name>
          <Gene-nomenclature_source>
            <Dbtag>
              <Dbtag_db>HGNC</Dbtag_db>
              <Dbtag_tag>
                <Object-id>
                  <Object-id_str>HGNC:7</Object-id_str>
                </Object-id>
              </Dbtag_tag>
            </Dbtag>
          </Gene-nomenclature_source>
        </Gene-nomenclature>
      </Gene-ref_formal-name>
    </Gene-ref>
  </Entrezgene_gene>
  <Entrezgene_prot>
    <Prot-ref>
      <Prot-ref_name>
        <Prot-ref_name_E>C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5</Prot-ref_name_E>
        <Prot-ref_name_E>alpha-2-M</Prot-ref_name_E>
      </Prot-ref_name>
      <Prot-ref_desc>alpha-2-macroglobulin</Prot-ref_desc>
    </Prot-ref>
  </Entrezgene_prot>
  <Entrezgene_summary>The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer&apos;s disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]</Entrezgene_summary>
  <Entrezgene_location>
    <Maps>
      <Maps_display-str>12p13.31</Maps_display-str>
      <Maps_method>
        <Maps_method_map-type value="cyto"/>
      </Maps_method>
    </Maps>
  </Entrezgene_location>
  <Entrezgene_gene-source>
    <Gene-source>
      <Gene-source_src>LocusLink</Gene-source_src>
      <Gene-source_src-int>2</Gene-source_src-int>
      <Gene-source_src-str2>2</Gene-source_src-str2>
    </Gene-source>
  </Entrezgene_gene-source>
  <Entrezgene_locus>
    <Gene-commentary>
      <Gene-commentary_type value="genomic">1</Gene-commentary_type>
      <Gene-commentary_heading>Reference GRCh38.p14 Primary Assembly</Gene-commentary_heading>
      <Gene-commentary_label>Chromosome 12 Reference GRCh38.p14 Primary Assembly</Gene-commentary_label>
      <Gene-commentary_accession>NC_000012</Gene-commentary_accession>
      <Gene-commentary_version>12</Gene-commentary_version>
      <Gene-commentary_seqs>
        <Seq-loc>
          <Seq-loc_int>
            <Seq-interval>
              <Seq-interval_from>9067707</Seq-interval_from>
              <Seq-interval_to>9116228</Seq-interval_to>
              <Seq-interval_strand>
                <Na-strand value="minus"/>
              </Seq-interval_strand>
              <Seq-interval_id>
                <Seq-id>
                  <Seq-id_gi>568815586</Seq-id_gi>
                </Seq-id>
              </Seq-interval_id>
            </Seq-interval>
          </Seq-loc_int>
        </Seq-loc>
      </Gene-commentary_seqs>
      <Gene-commentary_products>
        <Gene-commentary>
          <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
          <Gene-commentary_heading>Reference</Gene-commentary_heading>
          <Gene-commentary_label>transcript variant 2</Gene-commentary_label>
          <Gene-commentary_accession>NM_001347423</Gene-commentary_accession>
          <Gene-commentary_version>2</Gene-commentary_version>
          <Gene-commentary_genomic-coords>
            <Seq-loc>
              <Seq-loc_mix>
                <Seq-loc-mix>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>9116127</Seq-interval_from>
                        <Seq-interval_to>9116228</Seq-interval_to>
                        <Seq-interval_strand>
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                        </Seq-interval_strand>
                        <Seq-interval_id>
                          <Seq-id>
                            <Seq-id_gi>568815586</Seq-id_gi>
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                      </Seq-interval>
                    </Seq-loc_int>
                  </Seq-loc>
                  <Seq-loc>
                    <Seq-loc_int>
                      <Seq-interval>
                        <Seq-interval_from>9115763</Seq-interval_from>
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                    </Seq-loc_int>
                  </Seq-loc>
                  <Seq-loc>
                    <Seq-loc_int>
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                        <Seq-interval_from>9113359</Seq-interval_from>
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                  <Seq-loc>
                    <Seq-loc_int>
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                        <Seq-interval_from>9112376</Seq-interval_from>
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                                <Seq-id_gi>2194973269</Seq-id_gi>
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                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>9059886</Seq-interval_from>
                            <Seq-interval_to>9060042</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="minus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>2194973269</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
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                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>9059531</Seq-interval_from>
                            <Seq-interval_to>9059605</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="minus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>2194973269</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>9058941</Seq-interval_from>
                            <Seq-interval_to>9059121</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="minus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>2194973269</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>9056745</Seq-interval_from>
                            <Seq-interval_to>9056968</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="minus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>2194973269</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>9054837</Seq-interval_from>
                            <Seq-interval_to>9055055</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="minus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>2194973269</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>9054543</Seq-interval_from>
                            <Seq-interval_to>9054670</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="minus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>2194973269</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>9052672</Seq-interval_from>
                            <Seq-interval_to>9052762</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="minus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>2194973269</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>9051929</Seq-interval_from>
                            <Seq-interval_to>9051997</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="minus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>2194973269</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>9050924</Seq-interval_from>
                            <Seq-interval_to>9051026</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="minus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>2194973269</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>9050367</Seq-interval_from>
                            <Seq-interval_to>9050408</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="minus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>2194973269</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                      <Seq-loc>
                        <Seq-loc_int>
                          <Seq-interval>
                            <Seq-interval_from>9050007</Seq-interval_from>
                            <Seq-interval_to>9050023</Seq-interval_to>
                            <Seq-interval_strand>
                              <Na-strand value="minus"/>
                            </Seq-interval_strand>
                            <Seq-interval_id>
                              <Seq-id>
                                <Seq-id_gi>2194973269</Seq-id_gi>
                              </Seq-id>
                            </Seq-interval_id>
                          </Seq-interval>
                        </Seq-loc_int>
                      </Seq-loc>
                    </Seq-loc-mix>
                  </Seq-loc_mix>
                </Seq-loc>
              </Gene-commentary_genomic-coords>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>1779421278</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
      </Gene-commentary_products>
    </Gene-commentary>
  </Entrezgene_locus>
  <Entrezgene_properties>
    <Gene-commentary>
      <Gene-commentary_type value="property">16</Gene-commentary_type>
      <Gene-commentary_label>Exon count</Gene-commentary_label>
      <Gene-commentary_text>37</Gene-commentary_text>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_heading>GeneOntology</Gene-commentary_heading>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_pre-text>Provided by</Other-source_pre-text>
          <Other-source_anchor>GOA</Other-source_anchor>
          <Other-source_url>http://www.ebi.ac.uk/GOA</Other-source_url>
        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_comment>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_label>Function</Gene-commentary_label>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>48403</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>brain-derived neurotrophic factor binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>15226301</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>48306</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>calcium-dependent protein binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IPI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4866</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>endopeptidase inhibitor activity</Other-source_anchor>
                  <Other-source_post-text>evidence: IBA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7679575</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4866</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>endopeptidase inhibitor activity</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>11435418</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>19899</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>enzyme binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IPI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9398211</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>19838</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>growth factor binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>42802</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>identical protein binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9714181</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>19966</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>interleukin-1 binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>10880251</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>19959</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>interleukin-8 binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IPI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>48406</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>nerve growth factor binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2020</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>protease binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IBA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>7679575</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>18485748</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2020</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>protease binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IPI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>6698368</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>14687906</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>32814053</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5515</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>protein binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IPI</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>12538697</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4867</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>serine-type endopeptidase inhibitor activity</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>15226301</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5102</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>signaling receptor binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IMP</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>9714181</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>43120</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>enables</Other-source_pre-text>
                  <Other-source_anchor>tumor necrosis factor binding</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_label>Process</Gene-commentary_label>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2438</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>acute inflammatory response to antigenic stimulus</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6953</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>acute-phase response</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1990402</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>embryonic liver development</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1553</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>luteinization</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>12538697</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1869</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of complement activation, lectin pathway</Other-source_anchor>
                  <Other-source_post-text>evidence: IDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10466</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>negative regulation of peptidase activity</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10037</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>response to carbon dioxide</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>51384</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>response to glucocorticoid</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7584</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>response to nutrient</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>34695</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>response to prostaglandin E</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>48863</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>involved_in</Other-source_pre-text>
                  <Other-source_anchor>stem cell differentiation</Other-source_anchor>
                  <Other-source_post-text>evidence: IEA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_label>Component</Gene-commentary_label>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>22516433</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>72562</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>blood microparticle</Other-source_anchor>
                  <Other-source_post-text>evidence: HDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>28327460</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>62023</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>colocalizes_with</Other-source_pre-text>
                  <Other-source_anchor>collagen-containing extracellular matrix</Other-source_anchor>
                  <Other-source_post-text>evidence: HDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>25037231</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>28675934</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>62023</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>collagen-containing extracellular matrix</Other-source_anchor>
                  <Other-source_post-text>evidence: HDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>20458337</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>21362503</PubMedId>
                  </Pub_pmid>
                </Pub>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>23533145</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>70062</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>extracellular exosome</Other-source_anchor>
                  <Other-source_post-text>evidence: HDA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_refs>
                <Pub>
                  <Pub_pmid>
                    <PubMedId>14718574</PubMedId>
                  </Pub_pmid>
                </Pub>
              </Gene-commentary_refs>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5576</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>extracellular region</Other-source_anchor>
                  <Other-source_post-text>evidence: NAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5576</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>extracellular region</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5615</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>is_active_in</Other-source_pre-text>
                  <Other-source_anchor>extracellular space</Other-source_anchor>
                  <Other-source_post-text>evidence: IBA</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="comment">254</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GO</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>31093</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_pre-text>located_in</Other-source_pre-text>
                  <Other-source_anchor>platelet alpha granule lumen</Other-source_anchor>
                  <Other-source_post-text>evidence: TAS</Other-source_post-text>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
      </Gene-commentary_comment>
    </Gene-commentary>
  </Entrezgene_properties>
  <Entrezgene_comments>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_heading>RefSeq Status</Gene-commentary_heading>
      <Gene-commentary_label>REVIEWED</Gene-commentary_label>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_heading>Clone Names</Gene-commentary_heading>
      <Gene-commentary_text>DKFZp779B086</Gene-commentary_text>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="gene-group">23</Gene-commentary_type>
      <Gene-commentary_heading>Related pseudogene(s)</Gene-commentary_heading>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_pre-text>1 found</Other-source_pre-text>
          <Other-source_anchor>Review record(s) in Gene</Other-source_anchor>
        </Other-source>
      </Gene-commentary_source>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>38774923</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38407963</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38235627</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>38160662</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>37705485</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>37487878</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>37213155</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>36894970</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>36883061</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>36102452</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>35451533</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>34958020</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>34478776</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>33643290</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>32957873</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>32915361</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>32814053</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>32559179</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>32541810</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>32163666</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>31995266</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>31506491</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>31243924</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>30767554</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>30564965</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>30479021</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>29659051</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>29093276</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>29036223</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>28887505</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>28705706</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>28675934</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>28327460</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>28215695</PubMedId>
          </Pub_pmid>
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        <Pub>
          <Pub_pmid>
            <PubMedId>28087279</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>27872486</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>27862254</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>27839872</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>27788907</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>27498393</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>27228572</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>27090037</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>27044074</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>27031486</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>27002159</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>26971636</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>26823978</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>26688386</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>26476541</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>26385167</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>26289409</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>26217017</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>26173077</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
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            <PubMedId>6153632</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>3289986</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>2581245</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>2476070</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>2460294</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>2459995</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>2430963</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>2408344</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>1707161</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>1697852</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>1692292</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>1374237</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>1370808</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>1281457</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>89758</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>59727</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_heading>NCBI Reference Sequences (RefSeq)</Gene-commentary_heading>
      <Gene-commentary_comment>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_heading>RefSeqs maintained independently of Annotated Genomes</Gene-commentary_heading>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
              <Gene-commentary_heading>mRNA Sequence</Gene-commentary_heading>
              <Gene-commentary_accession>NM_000014</Gene-commentary_accession>
              <Gene-commentary_version>6</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1779421316</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NM_000014</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>1779421316</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
              <Gene-commentary_products>
                <Gene-commentary>
                  <Gene-commentary_type value="peptide">8</Gene-commentary_type>
                  <Gene-commentary_heading>Product</Gene-commentary_heading>
                  <Gene-commentary_accession>NP_000005</Gene-commentary_accession>
                  <Gene-commentary_version>3</Gene-commentary_version>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Protein</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_id>1779421317</Object-id_id>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>NP_000005</Other-source_anchor>
                      <Other-source_post-text>alpha-2-macroglobulin isoform a precursor</Other-source_post-text>
                    </Other-source>
                  </Gene-commentary_source>
                  <Gene-commentary_seqs>
                    <Seq-loc>
                      <Seq-loc_whole>
                        <Seq-id>
                          <Seq-id_gi>1779421317</Seq-id_gi>
                        </Seq-id>
                      </Seq-loc_whole>
                    </Seq-loc>
                  </Gene-commentary_seqs>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Conserved Domains</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_pre-text>(7)</Other-source_pre-text>
                          <Other-source_anchor>summary</Other-source_anchor>
                        </Other-source>
                      </Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>239227</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>cd02897: A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP).  Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 958 - 1264</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>395153</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam00207: A2M; Alpha-2-macroglobulin family</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 738 - 828</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>396416</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam01835: A2M_N; MG2 domain</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 129 - 221</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>400149</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam07677: A2M_recep; A-macroglobulin receptor</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 1376 - 1463</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>400170</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam07703: A2M_N_2; Alpha-2-macroglobulin family N-terminal region</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 459 - 607</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>407661</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam17789: MG4; Macroglobulin domain MG4</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 350 - 445</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>407663</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam17791: MG3; Macroglobulin domain MG3</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 223 - 313</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Related</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_src>
                            <Dbtag>
                              <Dbtag_db>Ensembl</Dbtag_db>
                              <Dbtag_tag>
                                <Object-id>
                                  <Object-id_str>ENSP00000323929.8</Object-id_str>
                                </Object-id>
                              </Dbtag_tag>
                            </Dbtag>
                          </Other-source_src>
                        </Other-source>
                      </Gene-commentary_source>
                    </Gene-commentary>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>UniProtKB</Gene-commentary_heading>
                      <Gene-commentary_source></Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>P01023</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>P01023</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q13677</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q13677</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q59F47</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q59F47</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q5QTS0</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q5QTS0</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q68DN2</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q68DN2</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q6PIY3</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q6PIY3</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q6PN97</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q6PN97</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Consensus CDS (CCDS)</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_src>
                            <Dbtag>
                              <Dbtag_db>CCDS</Dbtag_db>
                              <Dbtag_tag>
                                <Object-id>
                                  <Object-id_str>CCDS44827.1</Object-id_str>
                                </Object-id>
                              </Dbtag_tag>
                            </Dbtag>
                          </Other-source_src>
                          <Other-source_anchor>CCDS44827.1</Other-source_anchor>
                        </Other-source>
                      </Gene-commentary_source>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
              </Gene-commentary_products>
              <Gene-commentary_comment>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_label>RefSeq Status</Gene-commentary_label>
                  <Gene-commentary_text>REVIEWED</Gene-commentary_text>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_heading>Transcriptional Variant</Gene-commentary_heading>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="comment">254</Gene-commentary_type>
                      <Gene-commentary_text>Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.</Gene-commentary_text>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                  <Gene-commentary_heading>Source Sequence</Gene-commentary_heading>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Nucleotide</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_str>AC007436</Object-id_str>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>AC007436</Other-source_anchor>
                    </Other-source>
                  </Gene-commentary_source>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                  <Gene-commentary_heading>Related</Gene-commentary_heading>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Ensembl</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_str>ENST00000318602.12</Object-id_str>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                    </Other-source>
                  </Gene-commentary_source>
                </Gene-commentary>
              </Gene-commentary_comment>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
              <Gene-commentary_heading>mRNA Sequence</Gene-commentary_heading>
              <Gene-commentary_accession>NM_001347423</Gene-commentary_accession>
              <Gene-commentary_version>2</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1677538580</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NM_001347423</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>1677538580</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
              <Gene-commentary_products>
                <Gene-commentary>
                  <Gene-commentary_type value="peptide">8</Gene-commentary_type>
                  <Gene-commentary_heading>Product</Gene-commentary_heading>
                  <Gene-commentary_accession>NP_001334352</Gene-commentary_accession>
                  <Gene-commentary_version>2</Gene-commentary_version>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Protein</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_id>1677538581</Object-id_id>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>NP_001334352</Other-source_anchor>
                      <Other-source_post-text>alpha-2-macroglobulin isoform a precursor</Other-source_post-text>
                    </Other-source>
                  </Gene-commentary_source>
                  <Gene-commentary_seqs>
                    <Seq-loc>
                      <Seq-loc_whole>
                        <Seq-id>
                          <Seq-id_gi>1677538581</Seq-id_gi>
                        </Seq-id>
                      </Seq-loc_whole>
                    </Seq-loc>
                  </Gene-commentary_seqs>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Conserved Domains</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_pre-text>(7)</Other-source_pre-text>
                          <Other-source_anchor>summary</Other-source_anchor>
                        </Other-source>
                      </Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>239227</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>cd02897: A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP).  Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 958 - 1264</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>395153</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam00207: A2M; Alpha-2-macroglobulin family</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 738 - 828</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>396416</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam01835: A2M_N; MG2 domain</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 129 - 221</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>400149</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam07677: A2M_recep; A-macroglobulin receptor</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 1376 - 1463</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>400170</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam07703: A2M_N_2; Alpha-2-macroglobulin family N-terminal region</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 459 - 607</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>407661</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam17789: MG4; Macroglobulin domain MG4</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 350 - 445</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>407663</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam17791: MG3; Macroglobulin domain MG3</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 223 - 313</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>UniProtKB</Gene-commentary_heading>
                      <Gene-commentary_source></Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>P01023</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>P01023</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q13677</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q13677</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q59F47</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q59F47</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q5QTS0</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q5QTS0</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q68DN2</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q68DN2</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q6PIY3</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q6PIY3</Other-source_anchor>
                            </Other-source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_str>Q6PN97</Object-id_str>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>Q6PN97</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Consensus CDS (CCDS)</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_src>
                            <Dbtag>
                              <Dbtag_db>CCDS</Dbtag_db>
                              <Dbtag_tag>
                                <Object-id>
                                  <Object-id_str>CCDS44827.1</Object-id_str>
                                </Object-id>
                              </Dbtag_tag>
                            </Dbtag>
                          </Other-source_src>
                          <Other-source_anchor>CCDS44827.1</Other-source_anchor>
                        </Other-source>
                      </Gene-commentary_source>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
              </Gene-commentary_products>
              <Gene-commentary_comment>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_label>RefSeq Status</Gene-commentary_label>
                  <Gene-commentary_text>REVIEWED</Gene-commentary_text>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_heading>Transcriptional Variant</Gene-commentary_heading>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="comment">254</Gene-commentary_type>
                      <Gene-commentary_text>Transcript Variant: This variant (2) splices out a region of the 5&apos; UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).</Gene-commentary_text>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                  <Gene-commentary_heading>Source Sequence</Gene-commentary_heading>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Nucleotide</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_str>AC007436</Object-id_str>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>AC007436</Other-source_anchor>
                    </Other-source>
                  </Gene-commentary_source>
                </Gene-commentary>
              </Gene-commentary_comment>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
              <Gene-commentary_heading>mRNA Sequence</Gene-commentary_heading>
              <Gene-commentary_accession>NM_001347424</Gene-commentary_accession>
              <Gene-commentary_version>2</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1779421277</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NM_001347424</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>1779421277</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
              <Gene-commentary_products>
                <Gene-commentary>
                  <Gene-commentary_type value="peptide">8</Gene-commentary_type>
                  <Gene-commentary_heading>Product</Gene-commentary_heading>
                  <Gene-commentary_accession>NP_001334353</Gene-commentary_accession>
                  <Gene-commentary_version>2</Gene-commentary_version>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Protein</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_id>1779421278</Object-id_id>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>NP_001334353</Other-source_anchor>
                      <Other-source_post-text>alpha-2-macroglobulin isoform b</Other-source_post-text>
                    </Other-source>
                  </Gene-commentary_source>
                  <Gene-commentary_seqs>
                    <Seq-loc>
                      <Seq-loc_whole>
                        <Seq-id>
                          <Seq-id_gi>1779421278</Seq-id_gi>
                        </Seq-id>
                      </Seq-loc_whole>
                    </Seq-loc>
                  </Gene-commentary_seqs>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Conserved Domains</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_pre-text>(7)</Other-source_pre-text>
                          <Other-source_anchor>summary</Other-source_anchor>
                        </Other-source>
                      </Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>239227</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>cd02897: A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP).  Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 858 - 1164</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>365945</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam00207: A2M; Alpha-2-macroglobulin family</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 638 - 728</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>369460</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam07677: A2M_recep; A-macroglobulin receptor</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 1276 - 1363</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>375332</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam17789: MG4; Macroglobulin domain MG4</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 250 - 345</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>375334</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam17791: MG3; Macroglobulin domain MG3</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 123 - 210</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>376626</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam01835: A2M_N; MG2 domain</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 29 - 121</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>377903</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam07703: A2M_N_2; Alpha-2-macroglobulin family N-terminal region</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 359 - 507</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
              </Gene-commentary_products>
              <Gene-commentary_comment>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_label>RefSeq Status</Gene-commentary_label>
                  <Gene-commentary_text>REVIEWED</Gene-commentary_text>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_heading>Transcriptional Variant</Gene-commentary_heading>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="comment">254</Gene-commentary_type>
                      <Gene-commentary_text>Transcript Variant: This variant (3) contains an alternate splice site in the 5&apos; region, and it thus differs in its 5&apos; UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.</Gene-commentary_text>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                  <Gene-commentary_heading>Source Sequence</Gene-commentary_heading>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Nucleotide</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_str>AC007436</Object-id_str>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>AC007436</Other-source_anchor>
                    </Other-source>
                  </Gene-commentary_source>
                </Gene-commentary>
              </Gene-commentary_comment>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
              <Gene-commentary_heading>mRNA Sequence</Gene-commentary_heading>
              <Gene-commentary_accession>NM_001347425</Gene-commentary_accession>
              <Gene-commentary_version>2</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1779421327</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NM_001347425</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>1779421327</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
              <Gene-commentary_products>
                <Gene-commentary>
                  <Gene-commentary_type value="peptide">8</Gene-commentary_type>
                  <Gene-commentary_heading>Product</Gene-commentary_heading>
                  <Gene-commentary_accession>NP_001334354</Gene-commentary_accession>
                  <Gene-commentary_version>2</Gene-commentary_version>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Protein</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_id>1779421328</Object-id_id>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>NP_001334354</Other-source_anchor>
                      <Other-source_post-text>alpha-2-macroglobulin isoform c</Other-source_post-text>
                    </Other-source>
                  </Gene-commentary_source>
                  <Gene-commentary_seqs>
                    <Seq-loc>
                      <Seq-loc_whole>
                        <Seq-id>
                          <Seq-id_gi>1779421328</Seq-id_gi>
                        </Seq-id>
                      </Seq-loc_whole>
                    </Seq-loc>
                  </Gene-commentary_seqs>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="other">255</Gene-commentary_type>
                      <Gene-commentary_heading>Conserved Domains</Gene-commentary_heading>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_pre-text>(7)</Other-source_pre-text>
                          <Other-source_anchor>summary</Other-source_anchor>
                        </Other-source>
                      </Gene-commentary_source>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>239227</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>cd02897: A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP).  Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 808 - 1114</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>365945</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam00207: A2M; Alpha-2-macroglobulin family</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 588 - 678</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>369460</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam07677: A2M_recep; A-macroglobulin receptor</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 1226 - 1313</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>375332</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam17789: MG4; Macroglobulin domain MG4</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 200 - 295</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>375334</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam17791: MG3; Macroglobulin domain MG3</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 73 - 160</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>376626</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam01835: A2M_N; MG2 domain</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 1 - 71</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_src>
                                <Dbtag>
                                  <Dbtag_db>CDD</Dbtag_db>
                                  <Dbtag_tag>
                                    <Object-id>
                                      <Object-id_id>377903</Object-id_id>
                                    </Object-id>
                                  </Dbtag_tag>
                                </Dbtag>
                              </Other-source_src>
                              <Other-source_anchor>pfam07703: A2M_N_2; Alpha-2-macroglobulin family N-terminal region</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_text>Location: 309 - 457</Gene-commentary_text>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
              </Gene-commentary_products>
              <Gene-commentary_comment>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_label>RefSeq Status</Gene-commentary_label>
                  <Gene-commentary_text>REVIEWED</Gene-commentary_text>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="comment">254</Gene-commentary_type>
                  <Gene-commentary_heading>Transcriptional Variant</Gene-commentary_heading>
                  <Gene-commentary_comment>
                    <Gene-commentary>
                      <Gene-commentary_type value="comment">254</Gene-commentary_type>
                      <Gene-commentary_text>Transcript Variant: This variant (4) lacks an exon in the 5&apos; region, and it thus differs in its 5&apos; UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.</Gene-commentary_text>
                    </Gene-commentary>
                  </Gene-commentary_comment>
                </Gene-commentary>
                <Gene-commentary>
                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                  <Gene-commentary_heading>Source Sequence</Gene-commentary_heading>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Nucleotide</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_str>AC007436</Object-id_str>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                      <Other-source_anchor>AC007436</Other-source_anchor>
                    </Other-source>
                  </Gene-commentary_source>
                </Gene-commentary>
              </Gene-commentary_comment>
            </Gene-commentary>
          </Gene-commentary_products>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="genomic">1</Gene-commentary_type>
              <Gene-commentary_label>RefSeqGene</Gene-commentary_label>
              <Gene-commentary_accession>NG_011717</Gene-commentary_accession>
              <Gene-commentary_version>2</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1988243417</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NG_011717</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>LRG</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>LRG_591</Object-id_str>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LRG_591</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_int>
                    <Seq-interval>
                      <Seq-interval_from>5043</Seq-interval_from>
                      <Seq-interval_to>53254</Seq-interval_to>
                      <Seq-interval_strand>
                        <Na-strand value="plus"/>
                      </Seq-interval_strand>
                      <Seq-interval_id>
                        <Seq-id>
                          <Seq-id_gi>1988243417</Seq-id_gi>
                        </Seq-id>
                      </Seq-interval_id>
                    </Seq-interval>
                  </Seq-loc_int>
                </Seq-loc>
              </Gene-commentary_seqs>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_heading>RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</Gene-commentary_heading>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="genomic">1</Gene-commentary_type>
              <Gene-commentary_heading>Reference GRCh38.p14 Primary Assembly</Gene-commentary_heading>
              <Gene-commentary_accession>NC_000012</Gene-commentary_accession>
              <Gene-commentary_version>12</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>568815586</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_int>
                    <Seq-interval>
                      <Seq-interval_from>9067707</Seq-interval_from>
                      <Seq-interval_to>9116228</Seq-interval_to>
                      <Seq-interval_strand>
                        <Na-strand value="minus"/>
                      </Seq-interval_strand>
                      <Seq-interval_id>
                        <Seq-id>
                          <Seq-id_gi>568815586</Seq-id_gi>
                        </Seq-id>
                      </Seq-interval_id>
                    </Seq-interval>
                  </Seq-loc_int>
                </Seq-loc>
              </Gene-commentary_seqs>
              <Gene-commentary_products>
                <Gene-commentary>
                  <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
                  <Gene-commentary_accession>XM_006719056</Gene-commentary_accession>
                  <Gene-commentary_version>4</Gene-commentary_version>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Nucleotide</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_str>2217287982</Object-id_str>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                    </Other-source>
                  </Gene-commentary_source>
                  <Gene-commentary_seqs>
                    <Seq-loc>
                      <Seq-loc_whole>
                        <Seq-id>
                          <Seq-id_gi>2217287982</Seq-id_gi>
                        </Seq-id>
                      </Seq-loc_whole>
                    </Seq-loc>
                  </Gene-commentary_seqs>
                  <Gene-commentary_products>
                    <Gene-commentary>
                      <Gene-commentary_type value="peptide">8</Gene-commentary_type>
                      <Gene-commentary_accession>XP_006719119</Gene-commentary_accession>
                      <Gene-commentary_version>1</Gene-commentary_version>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_src>
                            <Dbtag>
                              <Dbtag_db>Protein</Dbtag_db>
                              <Dbtag_tag>
                                <Object-id>
                                  <Object-id_id>578822814</Object-id_id>
                                </Object-id>
                              </Dbtag_tag>
                            </Dbtag>
                          </Other-source_src>
                          <Other-source_anchor>XP_006719119</Other-source_anchor>
                          <Other-source_post-text>alpha-2-macroglobulin isoform X1</Other-source_post-text>
                        </Other-source>
                      </Gene-commentary_source>
                      <Gene-commentary_seqs>
                        <Seq-loc>
                          <Seq-loc_whole>
                            <Seq-id>
                              <Seq-id_gi>578822814</Seq-id_gi>
                            </Seq-id>
                          </Seq-loc_whole>
                        </Seq-loc>
                      </Gene-commentary_seqs>
                      <Gene-commentary_comment>
                        <Gene-commentary>
                          <Gene-commentary_type value="other">255</Gene-commentary_type>
                          <Gene-commentary_heading>Conserved Domains</Gene-commentary_heading>
                          <Gene-commentary_source>
                            <Other-source>
                              <Other-source_pre-text>(7)</Other-source_pre-text>
                              <Other-source_anchor>summary</Other-source_anchor>
                            </Other-source>
                          </Gene-commentary_source>
                          <Gene-commentary_comment>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_source>
                                <Other-source>
                                  <Other-source_src>
                                    <Dbtag>
                                      <Dbtag_db>CDD</Dbtag_db>
                                      <Dbtag_tag>
                                        <Object-id>
                                          <Object-id_id>225248</Object-id_id>
                                        </Object-id>
                                      </Dbtag_tag>
                                    </Dbtag>
                                  </Other-source_src>
                                  <Other-source_anchor>COG2373: YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family  [General function prediction only]</Other-source_anchor>
                                </Other-source>
                              </Gene-commentary_source>
                              <Gene-commentary_comment>
                                <Gene-commentary>
                                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                                  <Gene-commentary_text>Location: 124 - 1071</Gene-commentary_text>
                                </Gene-commentary>
                              </Gene-commentary_comment>
                            </Gene-commentary>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_source>
                                <Other-source>
                                  <Other-source_src>
                                    <Dbtag>
                                      <Dbtag_db>CDD</Dbtag_db>
                                      <Dbtag_tag>
                                        <Object-id>
                                          <Object-id_id>239227</Object-id_id>
                                        </Object-id>
                                      </Dbtag_tag>
                                    </Dbtag>
                                  </Other-source_src>
                                  <Other-source_anchor>cd02897: A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP).  Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...</Other-source_anchor>
                                </Other-source>
                              </Gene-commentary_source>
                              <Gene-commentary_comment>
                                <Gene-commentary>
                                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                                  <Gene-commentary_text>Location: 958 - 1264</Gene-commentary_text>
                                </Gene-commentary>
                              </Gene-commentary_comment>
                            </Gene-commentary>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_source>
                                <Other-source>
                                  <Other-source_src>
                                    <Dbtag>
                                      <Dbtag_db>CDD</Dbtag_db>
                                      <Dbtag_tag>
                                        <Object-id>
                                          <Object-id_id>278630</Object-id_id>
                                        </Object-id>
                                      </Dbtag_tag>
                                    </Dbtag>
                                  </Other-source_src>
                                  <Other-source_anchor>pfam00207: A2M; Alpha-2-macroglobulin family</Other-source_anchor>
                                </Other-source>
                              </Gene-commentary_source>
                              <Gene-commentary_comment>
                                <Gene-commentary>
                                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                                  <Gene-commentary_text>Location: 738 - 828</Gene-commentary_text>
                                </Gene-commentary>
                              </Gene-commentary_comment>
                            </Gene-commentary>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_source>
                                <Other-source>
                                  <Other-source_src>
                                    <Dbtag>
                                      <Dbtag_db>CDD</Dbtag_db>
                                      <Dbtag_tag>
                                        <Object-id>
                                          <Object-id_id>280081</Object-id_id>
                                        </Object-id>
                                      </Dbtag_tag>
                                    </Dbtag>
                                  </Other-source_src>
                                  <Other-source_anchor>pfam01835: A2M_N; MG2 domain</Other-source_anchor>
                                </Other-source>
                              </Gene-commentary_source>
                              <Gene-commentary_comment>
                                <Gene-commentary>
                                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                                  <Gene-commentary_text>Location: 129 - 221</Gene-commentary_text>
                                </Gene-commentary>
                              </Gene-commentary_comment>
                            </Gene-commentary>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_source>
                                <Other-source>
                                  <Other-source_src>
                                    <Dbtag>
                                      <Dbtag_db>CDD</Dbtag_db>
                                      <Dbtag_tag>
                                        <Object-id>
                                          <Object-id_id>284981</Object-id_id>
                                        </Object-id>
                                      </Dbtag_tag>
                                    </Dbtag>
                                  </Other-source_src>
                                  <Other-source_anchor>pfam07677: A2M_recep; A-macroglobulin receptor</Other-source_anchor>
                                </Other-source>
                              </Gene-commentary_source>
                              <Gene-commentary_comment>
                                <Gene-commentary>
                                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                                  <Gene-commentary_text>Location: 1376 - 1463</Gene-commentary_text>
                                </Gene-commentary>
                              </Gene-commentary_comment>
                            </Gene-commentary>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_source>
                                <Other-source>
                                  <Other-source_src>
                                    <Dbtag>
                                      <Dbtag_db>CDD</Dbtag_db>
                                      <Dbtag_tag>
                                        <Object-id>
                                          <Object-id_id>284982</Object-id_id>
                                        </Object-id>
                                      </Dbtag_tag>
                                    </Dbtag>
                                  </Other-source_src>
                                  <Other-source_anchor>pfam07678: A2M_comp; A-macroglobulin complement component</Other-source_anchor>
                                </Other-source>
                              </Gene-commentary_source>
                              <Gene-commentary_comment>
                                <Gene-commentary>
                                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                                  <Gene-commentary_text>Location: 1010 - 1266</Gene-commentary_text>
                                </Gene-commentary>
                              </Gene-commentary_comment>
                            </Gene-commentary>
                            <Gene-commentary>
                              <Gene-commentary_type value="other">255</Gene-commentary_type>
                              <Gene-commentary_source>
                                <Other-source>
                                  <Other-source_src>
                                    <Dbtag>
                                      <Dbtag_db>CDD</Dbtag_db>
                                      <Dbtag_tag>
                                        <Object-id>
                                          <Object-id_id>285005</Object-id_id>
                                        </Object-id>
                                      </Dbtag_tag>
                                    </Dbtag>
                                  </Other-source_src>
                                  <Other-source_anchor>pfam07703: A2M_N_2; Alpha-2-macroglobulin family N-terminal region</Other-source_anchor>
                                </Other-source>
                              </Gene-commentary_source>
                              <Gene-commentary_comment>
                                <Gene-commentary>
                                  <Gene-commentary_type value="other">255</Gene-commentary_type>
                                  <Gene-commentary_text>Location: 461 - 606</Gene-commentary_text>
                                </Gene-commentary>
                              </Gene-commentary_comment>
                            </Gene-commentary>
                          </Gene-commentary_comment>
                        </Gene-commentary>
                      </Gene-commentary_comment>
                    </Gene-commentary>
                  </Gene-commentary_products>
                </Gene-commentary>
              </Gene-commentary_products>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="genomic">1</Gene-commentary_type>
              <Gene-commentary_heading>Alternate T2T-CHM13v2.0</Gene-commentary_heading>
              <Gene-commentary_accession>NC_060936</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>2194973269</Object-id_str>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_int>
                    <Seq-interval>
                      <Seq-interval_from>9049892</Seq-interval_from>
                      <Seq-interval_to>9098415</Seq-interval_to>
                      <Seq-interval_strand>
                        <Na-strand value="minus"/>
                      </Seq-interval_strand>
                      <Seq-interval_id>
                        <Seq-id>
                          <Seq-id_gi>2194973269</Seq-id_gi>
                        </Seq-id>
                      </Seq-interval_id>
                    </Seq-interval>
                  </Seq-loc_int>
                </Seq-loc>
              </Gene-commentary_seqs>
              <Gene-commentary_products>
                <Gene-commentary>
                  <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
                  <Gene-commentary_accession>XM_054371391</Gene-commentary_accession>
                  <Gene-commentary_version>1</Gene-commentary_version>
                  <Gene-commentary_source>
                    <Other-source>
                      <Other-source_src>
                        <Dbtag>
                          <Dbtag_db>Nucleotide</Dbtag_db>
                          <Dbtag_tag>
                            <Object-id>
                              <Object-id_str>2462530588</Object-id_str>
                            </Object-id>
                          </Dbtag_tag>
                        </Dbtag>
                      </Other-source_src>
                    </Other-source>
                  </Gene-commentary_source>
                  <Gene-commentary_seqs>
                    <Seq-loc>
                      <Seq-loc_whole>
                        <Seq-id>
                          <Seq-id_gi>2462530588</Seq-id_gi>
                        </Seq-id>
                      </Seq-loc_whole>
                    </Seq-loc>
                  </Gene-commentary_seqs>
                  <Gene-commentary_products>
                    <Gene-commentary>
                      <Gene-commentary_type value="peptide">8</Gene-commentary_type>
                      <Gene-commentary_accession>XP_054227366</Gene-commentary_accession>
                      <Gene-commentary_version>1</Gene-commentary_version>
                      <Gene-commentary_source>
                        <Other-source>
                          <Other-source_src>
                            <Dbtag>
                              <Dbtag_db>Protein</Dbtag_db>
                              <Dbtag_tag>
                                <Object-id>
                                  <Object-id_str>2462530589</Object-id_str>
                                </Object-id>
                              </Dbtag_tag>
                            </Dbtag>
                          </Other-source_src>
                          <Other-source_anchor>XP_054227366</Other-source_anchor>
                          <Other-source_post-text>alpha-2-macroglobulin isoform X1</Other-source_post-text>
                        </Other-source>
                      </Gene-commentary_source>
                      <Gene-commentary_seqs>
                        <Seq-loc>
                          <Seq-loc_whole>
                            <Seq-id>
                              <Seq-id_gi>2462530589</Seq-id_gi>
                            </Seq-id>
                          </Seq-loc_whole>
                        </Seq-loc>
                      </Gene-commentary_seqs>
                    </Gene-commentary>
                  </Gene-commentary_products>
                </Gene-commentary>
              </Gene-commentary_products>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
      </Gene-commentary_comment>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_heading>Related Sequences</Gene-commentary_heading>
      <Gene-commentary_products>
        <Gene-commentary>
          <Gene-commentary_type value="genomic">1</Gene-commentary_type>
          <Gene-commentary_heading>Genomic</Gene-commentary_heading>
          <Gene-commentary_accession>AC007436</Gene-commentary_accession>
          <Gene-commentary_version>1</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>4726097</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>AC007436.1</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_int>
                <Seq-interval>
                  <Seq-interval_from>30684</Seq-interval_from>
                  <Seq-interval_to>79206</Seq-interval_to>
                  <Seq-interval_strand>
                    <Na-strand value="plus"/>
                  </Seq-interval_strand>
                  <Seq-interval_id>
                    <Seq-id>
                      <Seq-id_gi>4726097</Seq-id_gi>
                    </Seq-id>
                  </Seq-interval_id>
                </Seq-interval>
              </Seq-loc_int>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_text>None</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="genomic">1</Gene-commentary_type>
          <Gene-commentary_heading>Genomic</Gene-commentary_heading>
          <Gene-commentary_accession>AF349032</Gene-commentary_accession>
          <Gene-commentary_version>1</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>13661813</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>AF349032.1</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>13661813</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_accession>AAK38109</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>13661814</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>AAK38109.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>13661814</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="genomic">1</Gene-commentary_type>
          <Gene-commentary_heading>Genomic</Gene-commentary_heading>
          <Gene-commentary_accession>AF349033</Gene-commentary_accession>
          <Gene-commentary_version>1</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>13661815</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>AF349033.1</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>13661815</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_accession>AAK38110</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>13661816</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>AAK38110.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>13661816</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="genomic">1</Gene-commentary_type>
          <Gene-commentary_heading>Genomic</Gene-commentary_heading>
          <Gene-commentary_accession>CH471116</Gene-commentary_accession>
          <Gene-commentary_version>2</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>74230026</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>CH471116.2</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>74230026</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_accession>EAW88590</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>119608996</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>EAW88590.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>119608996</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="genomic">1</Gene-commentary_type>
          <Gene-commentary_heading>Genomic</Gene-commentary_heading>
          <Gene-commentary_accession>CP068266</Gene-commentary_accession>
          <Gene-commentary_version>2</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>2033710770</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>CP068266.2</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_int>
                <Seq-interval>
                  <Seq-interval_from>9049892</Seq-interval_from>
                  <Seq-interval_to>9098415</Seq-interval_to>
                  <Seq-interval_strand>
                    <Na-strand value="minus"/>
                  </Seq-interval_strand>
                  <Seq-interval_id>
                    <Seq-id>
                      <Seq-id_gi>2033710770</Seq-id_gi>
                    </Seq-id>
                  </Seq-interval_id>
                </Seq-interval>
              </Seq-loc_int>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_text>None</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="genomic">1</Gene-commentary_type>
          <Gene-commentary_heading>Genomic</Gene-commentary_heading>
          <Gene-commentary_accession>HF547954</Gene-commentary_accession>
          <Gene-commentary_version>1</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>440575712</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HF547954.1</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>440575712</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_accession>CCO13665</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>440575713</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CCO13665.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>440575713</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="genomic">1</Gene-commentary_type>
          <Gene-commentary_heading>Genomic</Gene-commentary_heading>
          <Gene-commentary_accession>MT894014</Gene-commentary_accession>
          <Gene-commentary_version>1</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>2029084498</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>MT894014.1</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>2029084498</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_accession>QUD18289</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2029084499</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>QUD18289.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>2029084499</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="genomic">1</Gene-commentary_type>
          <Gene-commentary_heading>Genomic</Gene-commentary_heading>
          <Gene-commentary_accession>MT894015</Gene-commentary_accession>
          <Gene-commentary_version>1</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>2029084500</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>MT894015.1</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>2029084500</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_accession>QUD18290</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2029084501</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>QUD18290.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>2029084501</Seq-id_gi>
                    </Seq-id>
                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="genomic">1</Gene-commentary_type>
          <Gene-commentary_heading>Genomic</Gene-commentary_heading>
          <Gene-commentary_accession>MT894016</Gene-commentary_accession>
          <Gene-commentary_version>1</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>2029084502</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>MT894016.1</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>2029084502</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_accession>QUD18291</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2029084503</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>QUD18291.1</Other-source_anchor>
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                </Dbtag>
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              <Other-source_src>
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              <Seq-loc_whole>
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        <Gene-commentary>
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                  </Dbtag_tag>
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              <Other-source_anchor>AK312482.1</Other-source_anchor>
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                <Dbtag>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
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              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
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        <Gene-commentary>
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          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
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                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BX504041.1</Other-source_anchor>
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          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>32028493</Seq-id_gi>
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            <Gene-commentary>
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            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
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          <Gene-commentary_accession>BX647329</Gene-commentary_accession>
          <Gene-commentary_version>1</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>34366357</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BX647329.1</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>34366357</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
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          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_text>None</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
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          <Gene-commentary_accession>BX648622</Gene-commentary_accession>
          <Gene-commentary_version>1</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>34367784</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BX648622.1</Other-source_anchor>
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          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>34367784</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
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          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_text>None</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
          <Gene-commentary_heading>mRNA</Gene-commentary_heading>
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          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
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                  </Dbtag_tag>
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                <Seq-id>
                  <Seq-id_gi>51476395</Seq-id_gi>
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              </Seq-loc_whole>
            </Seq-loc>
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          <Gene-commentary_products>
            <Gene-commentary>
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              <Gene-commentary_accession>CAH18188</Gene-commentary_accession>
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              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
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                  <Other-source_anchor>CAH18188.1</Other-source_anchor>
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              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>51476396</Seq-id_gi>
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                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
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          <Gene-commentary_accession>DB288732</Gene-commentary_accession>
          <Gene-commentary_version>1</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>83533639</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>DB288732.1</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>83533639</Seq-id_gi>
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              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_text>None</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
          <Gene-commentary_heading>mRNA</Gene-commentary_heading>
          <Gene-commentary_accession>DC334781</Gene-commentary_accession>
          <Gene-commentary_version>1</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>146127633</Object-id_id>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>DC334781.1</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>146127633</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_text>None</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
          <Gene-commentary_heading>mRNA</Gene-commentary_heading>
          <Gene-commentary_accession>DC402196</Gene-commentary_accession>
          <Gene-commentary_version>1</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>146051131</Object-id_id>
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                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>DC402196.1</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>146051131</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_text>None</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
          <Gene-commentary_heading>mRNA</Gene-commentary_heading>
          <Gene-commentary_accession>M11313</Gene-commentary_accession>
          <Gene-commentary_version>1</Gene-commentary_version>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
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                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>M11313.1</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>177869</Seq-id_gi>
                </Seq-id>
              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_accession>AAA51551</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
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                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>AAA51551.1</Other-source_anchor>
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              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>177870</Seq-id_gi>
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                </Seq-loc>
              </Gene-commentary_seqs>
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          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="mRNA">3</Gene-commentary_type>
          <Gene-commentary_heading>mRNA</Gene-commentary_heading>
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          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>Nucleotide</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
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                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>M36501.1</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_seqs>
            <Seq-loc>
              <Seq-loc_whole>
                <Seq-id>
                  <Seq-id_gi>177871</Seq-id_gi>
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              </Seq-loc_whole>
            </Seq-loc>
          </Gene-commentary_seqs>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_accession>AAA51552</Gene-commentary_accession>
              <Gene-commentary_version>1</Gene-commentary_version>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                  </Other-source_src>
                  <Other-source_anchor>AAA51552.1</Other-source_anchor>
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              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>177872</Seq-id_gi>
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                  </Seq-loc_whole>
                </Seq-loc>
              </Gene-commentary_seqs>
            </Gene-commentary>
          </Gene-commentary_products>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="other">255</Gene-commentary_type>
          <Gene-commentary_text>None</Gene-commentary_text>
          <Gene-commentary_products>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_accession>P01023</Gene-commentary_accession>
              <Gene-commentary_version>3</Gene-commentary_version>
              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
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                      </Dbtag_tag>
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                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>UniProtKB/Swiss-Prot</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_str>P01023.3</Object-id_str>
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                  <Other-source_anchor>UniProtKB/Swiss-Prot:P01023</Other-source_anchor>
                  <Other-source_url>https://www.uniprot.org/uniprot/P01023</Other-source_url>
                </Other-source>
              </Gene-commentary_source>
              <Gene-commentary_seqs>
                <Seq-loc>
                  <Seq-loc_whole>
                    <Seq-id>
                      <Seq-id_gi>308153640</Seq-id_gi>
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                  </Seq-loc_whole>
                </Seq-loc>
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          </Gene-commentary_products>
        </Gene-commentary>
      </Gene-commentary_products>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_heading>Additional Links</Gene-commentary_heading>
      <Gene-commentary_comment>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_text>MIM</Gene-commentary_text>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>MIM</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>103950</Object-id_id>
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                  </Dbtag_tag>
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              <Other-source_anchor>103950</Other-source_anchor>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>AceView</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>2</Object-id_id>
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                  </Dbtag_tag>
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              <Other-source_anchor>AceView</Other-source_anchor>
              <Other-source_url>https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&amp;org=9606&amp;l=2</Other-source_url>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_text>A2M database</Gene-commentary_text>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>A2M database</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
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                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>A2M database</Other-source_anchor>
              <Other-source_url>http://databases.lovd.nl/shared/genes/A2M</Other-source_url>
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          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_text>PharmGKB</Gene-commentary_text>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>PharmGKB</Dbtag_db>
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                    <Object-id>
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                  </Dbtag_tag>
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              <Other-source_anchor>PA24357</Other-source_anchor>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
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          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UCSC</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
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        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Production of Recombinant Polypeptides Binding alpha2-Macroglobulin and Analysis of Their Ability to Bind Human Serum alpha2-Macroglobulin.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32915361</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Interaction of Human Alpha-2-Macroglobulin with Pesticide Aldicarb Using Spectroscopy and Molecular Docking.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32957873</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The Role of Alpha 2 Macroglobulin in IgG-Aggregation and Chronic Activation of the Complement System in Patients With Chronic Lymphocytic Leukemia.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>33643290</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31995266</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The effect of adrenocorticotropic hormone on alpha-2-macroglobulin in osteoblasts derived from human mesenchymal stem cells.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32163666</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>GALNT6 promotes breast cancer metastasis by increasing mucin-type O-glycosylation of alpha2M.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32559179</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2021</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Activated alpha2-macroglobulin binding to cell surface GRP78 induces trophoblastic cell fusion.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>32541810</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>22</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Molecular form and concentration of serum alpha2-macroglobulin in diabetes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31506491</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The results suggest that A2M positively regulates Microvesicle shedding through the activation of LRP1 on myofibroblasts.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30479021</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>13</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Significantly lower levels of alpha-2-macroglobulin were found in the serum of patients with steroid-induced necrosis of the femoral head (SINFH) than in controls (P &lt; 0.05). Immunohistochemical staining and western blotting demonstrated that the expression of alpha-2-macroglobulin was significantly decreased in the necrotic area of SINFH patients (P &lt; 0.05).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>31243924</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>High A2M expression is associated with Pancreatic cancer.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30767554</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2020</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Impaired fibrinolysis and lower levels of alpha2-macroglobulin might predispose to a higher rate of asthma exacerbations, suggesting new links between disturbed hemostasis and asthma.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28887505</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In advanced prostate cancer with PSA levels &gt;1000 ng/mL, sufficient PSA-A2M is present in circulation to produce enzymatic activity against circulating small peptide hormones.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29659051</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the binding of IGFBP-2 to alpha2M seems to be related to structural changes in the glycan moieties of alpha2M, whereas binding of Zn ions, most likely, is not.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>30564965</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2019</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Serum alpha2MG levels might reflect endothelial dysfunction evaluated by flow-mediated dilation in patients with chronic stroke or cardiovascular risk factors</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29093276</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2018</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The blood coagulation pathway may be a key regulatory network pathway contributing to the allergic inflammatory response in AR patients. A2M, which is regulated by STAT3, may be an important protein in the pathogenesis of allergic rhinitis in AR patients.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27228572</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Proteomics study showed a strong association of FN1, A2M, C4BPA and CFB in molecular subtypes of breast cancer, in which, C4BPA and A2M demonstrated a potent signature in blood plasma and tissue samples of Luminal-B (LB) and Triple-negative (TN)subtypes in BC patients, respectively.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27498393</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>BBB disruption is present in ACS, and elevated levels of IL-6 and C3 in CSF in diffuse NPSLE</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>29036223</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Case Reports: inflammatory myofibroblastic tumors of the lung containing a chimeric A2M-ALK gene categorized as a specific type of inflammatory myofibroblastic tumor that develops exclusively in neonates and infants.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28705706</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The plasma level of alpha2M was found positively correlated, while HCII level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII may be potential biomarkers for evaluation of the vulnerability of carotid ...</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28087279</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Stabilizers during pasteurization improved alpha-2-macroglobulin (alpha2-M) activity by more than 300% points compared with the unstabilized control.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>28215695</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>22</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>16</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data show that low that low globulin (GLB) levels were significantly associated with favorable survival, and low ALB levels were associated with a significantly worse survival .</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26476541</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2017</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>30</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>This work demonstrates that alpha2M*/CS-GRP78 acts as an upstream regulator of the PDK1/PLK1 signaling axis to modulate c-MYC transcription and its target genes, suggesting a therapeutic strategy for targeting c-MYC-associated malignant progression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27002159</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>45</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Meta-analysis. Our data indicate that the rs669 (A/G) polymorphisms in A2M gene are associated with increased risk in Parkinson disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25495992</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>44</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data demonstrate that alpha2M* and LRP1 modulate the BKCachannel in human myometrium and that BKCaand its immunomodulatory interacting partners regulate Ca(2+)dynamics in hMSMCs during pregnancy.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>27044074</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>18</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>we identify a single serum factor, alpha2-macroglobulin (alpha2M), which is both required and sufficient for rosetting mediated by the parasite protein P. falciparum erythrocyte membrane protein 1 protein HB3VAR06 and some other rosette-mediating PfEMP1 proteins</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26134405</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>9</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A2M is expressed in the vasculature and NR4A receptors modulate VSMC MMP2/9 activity by several mechanisms including the up-regulation of A2M.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25809189</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>7</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Data indicate that the expression of salivary alpha2 macroglobulin (alpha2-M) showed a remarkable increase in type 2 diabetes mellitus (T2DM), which may be associated with functional disorders of the salivary gland.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25867373</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A2M is not the only biological candidate gene for AD determination</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>25574746</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2016</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>2</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alpha2M causes neurodegeneration in a p75(NTR)- and proNGF-dependent manner.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>26217017</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>there is no enough evidence for associations of A2M gene polymorphisms (5 bp I/D, Ile1000Val) with Alzheimer&apos;s disease risk</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24756728</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>5</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>phosphorylating the T-loop Akt residue Thr(308) by PDK1 requires Raptor of the mTORC1 complex as a platform or scaffold protein.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24516643</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2015</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>59</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>genetic variation within the A2M gene influences CSF Ab42 levels. </Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24011543</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
              <Date-std_minute>28</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>alpha2M is a specialized chaperone that prevents the extracellular accumulation of misfolded and potentially pathogenic proteins, particularly during innate immune system activity</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24799681</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>8</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>7</Date-std_month>
              <Date-std_day>19</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>46</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>FEIgG and alpha2m/C are powerful predictors of outcome and responsiveness to steroids and cyclophosphamide; their predictive value, if validated in prospective studies, may be useful in clinical practice</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>24093110</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There is no statistically significant difference in allele or genotype frequencies between patients with sporadic Alzheimer&apos;s disease and control subjects for the A2M polymorphism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23186781</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>53</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Eosinophil activation occurred in early and late responses after L-ASA NPT in upper airway mucosa of AERD patients, where ApoA1, alpha2M and CP as well as CysLT may be involved in eosinophilic inflammation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23786280</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2014</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>18</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin remains labile and available to down-regulate Fpn1.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23846698</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>alpha2macroglobulin stimulates endothelial and early cardiac muscle differentiation of embryonic stem cells through generation of induction of FGF-2 expression.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23379699</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>52</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Serum monomeric alpha2-macroglobulin is highly expressed in many diabetic subjects.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23535567</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>16</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>15</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>While activated alpha-2-microglobulin (AA2M) ligates only one GRP78 receptor molecule per AA2M, it may potentially serve as a reservoir for release of up to four binding fragments per molecule.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23721263</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Oxidative stress and the levels of endogenous plasma prolyl oligopeptidase (PREP) inhibitor alpha-2-macroglobulin (alpha2M) decrease PREP activity in patients with multiple sclerosis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23643808</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>IGFBP-2 associates with alpha2-macroglobulin in the blood circulation.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23397525</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>32</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>[review] alpha2M has many diversified and complex functions but is primarily known by its ability to inhibit a broad spectrum of proteases without the direct blockage of the protease active site.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23086799</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>19</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>protease-activated alpha2M has two mechanisms for inhibiting amyloid formation: via protease-alpha2M-mediated degradation of amyloidogenic substrates and by a chaperone action that prevents misfolded clients from continuing along the amyloid forming pathway.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23353684</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>29</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>inhibitory activity of Aeromonas sobria serine protease by alpha2-macroglobulin</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23089609</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>48</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Complexes between alpha2-macroglobulin and urokinase were detected in alveolar edema fluids as well as in lungs of patients with acute lung injury/acute respiratory distress syndrome where they were located mainly in close proximity to epithelial cells.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>23064953</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2013</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>23</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>an isoform of ASP cleaved proteins more in plasma and was inhibited by human alpha(2)-macroglobulin more slowly than single-chain ASP</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22971340</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>29</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>investigation of secondary structure and thermal stability of recombinant bodhesin 2, a spermadhesin from seminal plasma</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22541546</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>8</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>2</Date-std_hour>
              <Date-std_minute>14</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>alpha-2-macroglobulin (a2M) deficiency develops from catabolism of a2M in androgen-dependent advanced prostate cancer patients</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>22576683</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Ethnicity affects the genetic association of A2M with rheumatoid arthritis in South Asian and Caucasian patients living in East Midlands/United Kingdom.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20401725</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>30</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>49</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>We observed that the most informative biomarkers for predicting significant liver fibrosis in chronic hepatitis C patients were blood levels of alpha2-macroglobulin and hyaluronic acid</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21971609</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Identify a novel transcriptional regulatory element contributing to the up-regulation of alpha2M during replicative senescence.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21541797</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2012</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>55</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>alpha2-macroglobulin is neurotoxic by inhibiting neuroprotective activity of nerve growth factor via TrkA receptors.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21642630</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>54</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>dimeric alpha2M as well as tetrameric alpha2M may play an important role in controlling beta2-m amyloid fibril formation</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>21216953</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>10</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The extracellular chaperone alpha-2-macroglobulin is likely to help control amyloid formation and toxicity in vivo</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18075673</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The chaperone action of alpha-2-macroglobulin inhibits the toxicity and uptake of A beta in human cerebrospinal fluid</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19472074</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>42</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The chaperone action of alpha-2-macroglobulin targets prefibrillar species to inhibit amyloid formation</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19074141</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>4</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alpha-2-macroglobulin is an extracellular chaperone</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18171086</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>3</Date-std_day>
              <Date-std_hour>21</Date-std_hour>
              <Date-std_minute>39</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>16</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>statistically significant evidence of interaction between the polymorphisms in A2M, SLC6A4 and UCHL1 genes (global P = 0.0107, for the best model) and the risk for PD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20861575</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2011</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>26</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>LRP1-C/T, A2M-Ile/Val and APOE-epsilon 2/epsilon 3/epsilon 4 polymorphisms are associated with AD.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20637261</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>12</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Reduced expression of alpha-2 macroglobulin and complement factor B was detected in sera of patients with nasopharyngeal carcinoma.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20575108</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>56</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Haplotype -88G/25G might play a protective role in the development of SAD, and the protective effects of -88G and 25G were independent of APOEvarepsilon4 allele.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20493925</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>40</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Galectin-3 Binding Protein and Alpha-2 macroglobulin were differentially expressed on DVT patients in microparticles extracted from platelet-poor plasma</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20156641</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>27</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>38</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20628086</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_src>
            <Dbtag>
              <Dbtag_db>HuGENet</Dbtag_db>
              <Dbtag_tag>
                <Object-id>
                  <Object-id_str>2.20628086</Object-id_str>
                </Object-id>
              </Dbtag_tag>
            </Dbtag>
          </Other-source_src>
          <Other-source_anchor>HuGENet</Other-source_anchor>
        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>22</Date-std_hour>
              <Date-std_minute>5</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>22</Date-std_hour>
              <Date-std_minute>6</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>SP-D utilizes a novel mechanism in which the collectin interacts with protease inhibitor A2M to decrease its degradation and to concurrently increase its innate immune function.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20207732</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>5</Date-std_month>
              <Date-std_day>31</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>37</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These data support an involvement of the suggested A2M risk haplotype in the pathogenesis of Alzheimer&apos;s disease and adds new evidence to the risk-allele depletion hypothesis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19639019</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>26</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>LRP1 bound A2M* found to be associated with an inhibition of tumor cell proliferation, migration, invasion, spheroid formation, and anchorage-independent growth.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20048078</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>3</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>1</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>27</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A2M allele and genotype frequencies were similar between AD patients and controls.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18191876</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>An ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3 in Alzheimer disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19105203</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>11</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Results of this study revealed no association between the I1000V polymorphism of A2M and Chinese sporadic AD in Guangzhou and Chengdu.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15793779</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>both alpha(2)M and Hp are likely to play an important role in controlling the inappropriate aggregation of proteins in the extracellular environment.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>19074141</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2009</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>4</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Copper is taken up efficiently from albumin and alpha2-macroglobulin by cultured human cells by more than one mechanism.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18579803</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>11</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>effects of intact alpha(2)M on cell physiology reflect the degree of penetration of activities associated with different domains</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18499670</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>9</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Senile systemic amyloidosis was associated with age, myocardial infarctions, the G/G (Val/Val) genotype of the exon 24 polymorphism in the alpha2-macroglobulin (alpha2M), and the H2 haplotype of the tau gene</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18382889</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>6</Date-std_month>
              <Date-std_day>14</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alpha 2M activated by neutrophil elastase to its receptor-recognized form binds CpG ODN and enhances their immunostimulatory properties significantly.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17967834</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>4</Date-std_month>
              <Date-std_day>12</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>alpha2M is a newly discovered and unique member of a small group of abundant extracellular proteins with chaperone properties</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18171086</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>15</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Observational study and meta-analysis of gene-disease association. (HuGE Navigator)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15931081</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_src>
            <Dbtag>
              <Dbtag_db>HuGENet</Dbtag_db>
              <Dbtag_tag>
                <Object-id>
                  <Object-id_str>2.15931081</Object-id_str>
                </Object-id>
              </Dbtag_tag>
            </Dbtag>
          </Other-source_src>
          <Other-source_anchor>HuGENet</Other-source_anchor>
        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20637261</PubMedId>
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        <Pub>
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            <PubMedId>20493925</PubMedId>
          </Pub_pmid>
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        <Pub>
          <Pub_pmid>
            <PubMedId>20381197</PubMedId>
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        <Pub>
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            <PubMedId>16650578</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>15023809</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>14675603</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>11496365</PubMedId>
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        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
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              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
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        </Date>
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      <Gene-commentary_update-date>
        <Date>
          <Date_std>
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              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Observational study of gene-disease association. (HuGE Navigator)</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>20800603</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>20587546</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>20401725</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>19913121</PubMedId>
          </Pub_pmid>
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        <Pub>
          <Pub_pmid>
            <PubMedId>19105203</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>18706476</PubMedId>
          </Pub_pmid>
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        <Pub>
          <Pub_pmid>
            <PubMedId>18382889</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>16910174</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>16784755</PubMedId>
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        <Pub>
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            <PubMedId>16456795</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>16402284</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>16384981</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>16040006</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>15793779</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>15468911</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>14759632</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>14637088</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>12782964</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>12782337</PubMedId>
          </Pub_pmid>
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        <Pub>
          <Pub_pmid>
            <PubMedId>12394648</PubMedId>
          </Pub_pmid>
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        <Pub>
          <Pub_pmid>
            <PubMedId>12221172</PubMedId>
          </Pub_pmid>
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        <Pub>
          <Pub_pmid>
            <PubMedId>12123860</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>12059070</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>11987698</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>11901360</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>11498265</PubMedId>
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        <Pub>
          <Pub_pmid>
            <PubMedId>11484172</PubMedId>
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        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>11455130</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>11436125</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>11290389</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>11281447</PubMedId>
          </Pub_pmid>
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        <Pub>
          <Pub_pmid>
            <PubMedId>11231028</PubMedId>
          </Pub_pmid>
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        <Pub>
          <Pub_pmid>
            <PubMedId>11166925</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>11121179</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>11099722</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>11058789</PubMedId>
          </Pub_pmid>
        </Pub>
        <Pub>
          <Pub_pmid>
            <PubMedId>11036822</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_source>
        <Other-source>
          <Other-source_src>
            <Dbtag>
              <Dbtag_db>HuGENet</Dbtag_db>
              <Dbtag_tag>
                <Object-id>
                  <Object-id_str>2.11036822</Object-id_str>
                </Object-id>
              </Dbtag_tag>
            </Dbtag>
          </Other-source_src>
          <Other-source_anchor>HuGENet</Other-source_anchor>
        </Other-source>
      </Gene-commentary_source>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>8</Date-std_hour>
              <Date-std_minute>43</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>13</Date-std_day>
              <Date-std_hour>9</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Decreased expression of alpha2-M mRNA and protein and protease inhibitory activity in the vaginal wall tissues of women with stress urinary incontinence(SUI) may contribute to the development of SUI.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>18077315</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2008</Date-std_year>
              <Date-std_month>3</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>12</Date-std_hour>
              <Date-std_minute>11</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>expression and characterization of three alpha(2)M domains predicted to be involved in the stabilization of the thiol ester in native alpha2M and in its activation upon bait region proteolysis.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17608619</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>11</Date-std_month>
              <Date-std_day>10</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>alpha2-macroglobulin may facilitate conformational changes in prion protein in spontaneous forms of prion disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17453620</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>6</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>1</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These results suggest the possible involvement of cathepsin E in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12631277</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>has an important role in the AD-specific neurodegenerative process but its exon 24 Val-1000-Ile polymorphism is not likely to be associated with late-onset sporadic AD in the Hungarian population</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11901360</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>increased alpha(2)-macroglobulin expression appears to be associated with benign prostatic hyperplasia</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15611997</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>distinct binding sites mediate interaction with beta-amyloid peptide and growth factors</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11823454</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The three-dimensional structure of the dimer reveals its structural organization in the tetrameric native and chymotrypsin alpha 2-macroglobulin complexes.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12015318</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>These studies demonstrate that a single mutation in full-length r(alpha)2M is sufficient to block binding to LRP-1.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15910735</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results indicate that secondary proteolysis of alpha2-macroglobulin promotes impaired control of extracellular proteolytic activity, leading to local and distant tissue injuries during severe acute pancreatitis</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16232083</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alpha 2-macroglobulin enhances prothrombin activation and thrombin potential by inhibiting the anticoagulant protein C/protein S system in cord and adult plasma.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12062545</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A2M gene was suggested to be associated with Alzheimer&apos;s disease.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15931081</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Alpha2-macroglobulin is a substrate and an endogenous inhibitor for ADAMTS-4 and ADAMTS-5</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14715656</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>FGF-2 and this protein interact at specific binding sites, involving different FGF-2 sequences.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12755687</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>alpha(2)M-derived peptides target the receptor-binding sequence in TGF-beta</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12755614</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Differential binding to ldl receptor related protein</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11811950</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>the inhibition of proteases on the surface of microorganisms by an ancestral alpha2M-like thiol ester protein may generate &quot;arrays&quot; of oligomannose glycans to which MBL or other lectins can bind</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16407218</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>results did not support the hypothesis that A2M deletion polymorphism is associated with a low A2M concentration in overweight/obese subjects</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16910174</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic association of argyrophilic grain disease with polymorphisms in alpha-2 macroglobulin.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12175343</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>review of the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16297527</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>PAK-2 is activated in 1-LN prostate cancer cells by a proteinase inhibitor, alpha 2-macroglobulin</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15908432</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>REVIEW: binds and neutralizes alfimeprase, which has direct proteolytic activity against the fibrinogen Aalpha chain</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>11910179</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The presence of MPO-G/G and A2M-Val/Val genotypes synergistically increased the risk of AD (OR, 25.5; 95% CI, 4.65-139.75).</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15023809</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Genetic association of alpha2-macroglobulin polymorphisms with Alzheimer&apos;s disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12221172</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>an important involvement of alpha2M in regulation of increased proteolytic activity occurring in multiple sclerosis disease</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>15511627</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>alpha2-M deletion polymorphism is probably not associated with functional deficiencies important in Alzheimer&apos;s disease pathology</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14637088</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>PDGF-BB and TGF-beta1 binding to intact alpha2M is specific, involving a defined region of the alpha2M subunit</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16641085</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>In this proteins two amino acid polymorphisms (Ile/Val A--&gt;G) have been associated with an increased risk for Alzheimer&apos;s disease (AD) and the combination with CTSD-T allele seems to increase this risk.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>16784755</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>relationship between serum VEGF levels, alpha(2)M levels and the development of OHSS in hyperstimulated subjects undergoing IVF</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12042276</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>Plasma from patients homozygous for the intronic deletion (DD) showed normal alpha(2)M subunit size, conformation, and proteinase inhibitory activity. Plasma alpha(2)M from two DD patients showed markedly increased TGF-beta1 binding.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14678766</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>There is a significant genetic association of the 5 bp deletion and two novel polymorphisms in alpha-2-macroglobulin alpha-2-macroglobulin precursor with AD</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>12966032</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>bone morphogenetic protein 1 is inhibited by native and altered forms of alpha2-macroglobulin</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17071617</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>alpha(2)M* binding to LRP-1 induces cell proliferation and MAPK activation in the J774 macrophage-derived cell line</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17288987</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>The risk of symptomatic thromboembolism was significantly increased with elevated alpha2MG levels.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>17403113</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2007</Date-std_year>
              <Date-std_month>8</Date-std_month>
              <Date-std_day>25</Date-std_day>
              <Date-std_hour>10</Date-std_hour>
              <Date-std_minute>2</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>alpha2-macroglobulin inhibits human pepsin and gastricsin</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14506912</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2003</Date-std_year>
              <Date-std_month>10</Date-std_month>
              <Date-std_day>7</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_text>A2M-D allele played a weak Alzheimer disease protective role, and APOE-E4 and A2M-G alleles might act synergistically in Alzheimer disease risk for mainland Han Chinese.</Gene-commentary_text>
      <Gene-commentary_refs>
        <Pub>
          <Pub_pmid>
            <PubMedId>14675603</PubMedId>
          </Pub_pmid>
        </Pub>
      </Gene-commentary_refs>
      <Gene-commentary_create-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2004</Date-std_year>
              <Date-std_month>2</Date-std_month>
              <Date-std_day>17</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_create-date>
      <Gene-commentary_update-date>
        <Date>
          <Date_std>
            <Date-std>
              <Date-std_year>2010</Date-std_year>
              <Date-std_month>1</Date-std_month>
              <Date-std_day>21</Date-std_day>
              <Date-std_hour>0</Date-std_hour>
              <Date-std_minute>0</Date-std_minute>
              <Date-std_second>0</Date-std_second>
            </Date-std>
          </Date_std>
        </Date>
      </Gene-commentary_update-date>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_heading>HIV-1 protein interactions</Gene-commentary_heading>
      <Gene-commentary_comment>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of alpha-2-macroglobulin (A2M) in peptide-treated PBMCs</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>23383108</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>155971</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>env</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>19172954</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Envelope transmembrane glycoprotein gp41</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>66932947</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>alpha-2-macroglobulin isoform a precursor</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2014</Date-std_year>
                  <Date-std_month>6</Date-std_month>
                  <Date-std_day>19</Date-std_day>
                  <Date-std_hour>16</Date-std_hour>
                  <Date-std_minute>19</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2016</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>28</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Binding of HIV-1 Tat to LRP inhibits neuronal binding, uptake and degradation of physiological ligands for LRP, including alpha2-macroglobulin, apolipoprotein E4, amyloid precursor and amyloid beta-protein</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>11100124</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>155871</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>tat</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>9629358</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Tat</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>66932947</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>alpha-2-macroglobulin isoform a precursor</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2006</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>17</Date-std_hour>
                  <Date-std_minute>15</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2016</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>28</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>The cleavage site of alpha 2-Macroglobulin by HIV-1 protease is the Phe684-Tyr685 bond</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>7690356</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>7524416</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>1724156</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>155348</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>gag-pol</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>25121906</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>retropepsin</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>66932947</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>alpha-2-macroglobulin isoform a precursor</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2006</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>17</Date-std_hour>
                  <Date-std_minute>15</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2016</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>28</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
      </Gene-commentary_comment>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="generif">18</Gene-commentary_type>
      <Gene-commentary_heading>Interactions</Gene-commentary_heading>
      <Gene-commentary_comment>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>37132043</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>51132</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RLIM</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>119319</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>9</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>9</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>9</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>50</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Proximity Label-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>37059927</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>43740568</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>S</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4383848</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>11</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>47</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Cross-Linking-MS (XL-MS)</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>37343697</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2244</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>FGB</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>108535</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>11</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>17</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Cross-Linking-MS (XL-MS)</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>37343697</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1191</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CLU</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>107603</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>11</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>17</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Cross-Linking-MS (XL-MS)</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>37343697</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>335</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>APOA1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106832</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>11</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>17</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Cross-Linking-MS (XL-MS)</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>37343697</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>183</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>AGT</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106690</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>11</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>17</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Cross-Linking-MS (XL-MS)</Gene-commentary_text>
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                <PubMedId>34349018</PubMedId>
              </Pub_pmid>
            </Pub>
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                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
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            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>8359</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>H4C1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113955</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
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                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>13</Date-std_hour>
                  <Date-std_minute>12</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>30</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Cross-Linking-MS (XL-MS)</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>34349018</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>8347</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>H2BC4</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113943</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>13</Date-std_hour>
                  <Date-std_minute>12</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>30</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Cross-Linking-MS (XL-MS)</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>34349018</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3017</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>H2BC5</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>109270</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>13</Date-std_hour>
                  <Date-std_minute>12</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>13</Date-std_hour>
                  <Date-std_minute>19</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Cross-Linking-MS (XL-MS)</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>34349018</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1152</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CKB</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>107572</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>13</Date-std_hour>
                  <Date-std_minute>12</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>13</Date-std_hour>
                  <Date-std_minute>18</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Cross-Linking-MS (XL-MS)</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>34349018</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>293</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>SLC25A6</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106790</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>13</Date-std_hour>
                  <Date-std_minute>12</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>5</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>13</Date-std_hour>
                  <Date-std_minute>18</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>35906200</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>8295</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TRRAP</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113900</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>4</Date-std_month>
                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>11</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2024</Date-std_year>
                  <Date-std_month>4</Date-std_month>
                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>23</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS; Proximity Label-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>38496616</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>36244648</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5894</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RAF1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111831</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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            <Gene-commentary>
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              <Gene-commentary_source>
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            <Gene-commentary>
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            </Gene-commentary>
            <Gene-commentary>
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                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>41</Date-std_minute>
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                    <Dbtag>
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                      </Dbtag_tag>
                    </Dbtag>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
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                      </Dbtag_tag>
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            <Gene-commentary>
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                  <Date-std_minute>50</Date-std_minute>
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            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                          <Object-id_id>5159</Object-id_id>
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                      </Dbtag_tag>
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            </Gene-commentary>
            <Gene-commentary>
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              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
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                      </Dbtag_tag>
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            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_month>2</Date-std_month>
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                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>2</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
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              </Date_std>
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        </Gene-commentary>
        <Gene-commentary>
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              <Pub_pmid>
                <PubMedId>35384245</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7010</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>TEK</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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              </Gene-commentary_source>
            </Gene-commentary>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>18</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
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              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>36</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
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              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
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            <Pub>
              <Pub_pmid>
                <PubMedId>32687490</PubMedId>
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            </Pub>
          </Gene-commentary_refs>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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                <Other-source>
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                    <Dbtag>
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                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
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              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
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            <Pub>
              <Pub_pmid>
                <PubMedId>35944360</PubMedId>
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            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                    <Object-id>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>ZRANB1</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
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                      </Dbtag_tag>
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            <Date>
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                <Date-std>
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                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>19</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>29</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
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            <Pub>
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                <PubMedId>34316702</PubMedId>
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            </Pub>
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                <Dbtag>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RYBP</Other-source_anchor>
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                <Other-source>
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                    <Dbtag>
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                      </Dbtag_tag>
                    </Dbtag>
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              </Gene-commentary_source>
            </Gene-commentary>
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          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>21</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>4</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
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            <Pub>
              <Pub_pmid>
                <PubMedId>35605301</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
                          <Object-id_id>55230</Object-id_id>
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                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>USP40</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
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                        <Object-id>
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            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_day>9</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>9</Date-std_minute>
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                </Date-std>
              </Date_std>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_day>9</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>27</Date-std_minute>
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                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
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          <Gene-commentary_text>Co-fractionation</Gene-commentary_text>
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              <Pub_pmid>
                <PubMedId>35831314</PubMedId>
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                    <Dbtag>
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              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                    <Dbtag>
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            <Gene-commentary>
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              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                <Date-std>
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                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
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                <PubMedId>35831314</PubMedId>
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            </Pub>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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            <Gene-commentary>
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              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                    <Dbtag>
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            <Gene-commentary>
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                    <Dbtag>
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            <Gene-commentary>
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              <Gene-commentary_source>
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                    <Dbtag>
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                <PubMedId>33961781</PubMedId>
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            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>28514442</PubMedId>
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          <Gene-commentary_comment>
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                    <Dbtag>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
                          <Object-id_id>285203</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>EOGT</Other-source_anchor>
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                <Other-source>
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                    <Dbtag>
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                      <Dbtag_tag>
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            <Date>
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                <Date-std>
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            </Date>
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            <Date>
              <Date_std>
                <Date-std>
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        </Gene-commentary>
        <Gene-commentary>
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              <Pub_pmid>
                <PubMedId>33961781</PubMedId>
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            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>28514442</PubMedId>
              </Pub_pmid>
            </Pub>
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                <Dbtag>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
                          <Object-id_id>284207</Object-id_id>
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                      </Dbtag_tag>
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                    <Dbtag>
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                        <Object-id>
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            <Date>
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                <Date-std>
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            <Date>
              <Date_std>
                <Date-std>
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              </Date_std>
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        </Gene-commentary>
        <Gene-commentary>
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          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
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              <Pub_pmid>
                <PubMedId>33961781</PubMedId>
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            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>28514442</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>26186194</PubMedId>
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            </Pub>
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                <Dbtag>
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          <Gene-commentary_comment>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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                        <Object-id>
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            <Gene-commentary>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                    <Dbtag>
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                <Date-std>
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                <PubMedId>33961781</PubMedId>
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                  </Dbtag_tag>
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          <Gene-commentary_comment>
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              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
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                <Other-source>
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                <Date-std>
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                <PubMedId>31273033</PubMedId>
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            </Pub>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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            </Gene-commentary>
            <Gene-commentary>
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              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                    <Dbtag>
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                  <Date-std_hour>10</Date-std_hour>
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            <Date>
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                <Date-std>
                  <Date-std_year>2021</Date-std_year>
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                  <Date-std_day>9</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>5</Date-std_minute>
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              </Date_std>
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              <Pub_pmid>
                <PubMedId>7686585</PubMedId>
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            </Pub>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          <Gene-commentary_comment>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                <Date-std>
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          <Gene-commentary_text>Reconstituted Complex</Gene-commentary_text>
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                    <Dbtag>
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            </Gene-commentary>
            <Gene-commentary>
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              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6532</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>SLC6A4</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>112423</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2021</Date-std_year>
                  <Date-std_month>4</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>19</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2021</Date-std_year>
                  <Date-std_month>4</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>54</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Proximity Label-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>32529326</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4692</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NDN</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110772</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>17</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>16</Date-std_hour>
                  <Date-std_minute>4</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Protein-RNA</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31601781</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>100505817</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LINC02582</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1528023</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>9</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>17</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>9</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31992359</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>117854</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TRIM6</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>125596</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>9</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>17</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>9</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31343991</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>23113</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CUL9</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>116736</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>18</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>54</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>3643793</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3816</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>KLK1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110016</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>18</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>16</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31180492</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2177</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>FANCD2</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>108474</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>18</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2020</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>14</Date-std_hour>
                  <Date-std_minute>16</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>31300519</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
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                <PubMedId>29511261</PubMedId>
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            </Pub>
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              <Gene-commentary_source>
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                    <Dbtag>
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            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
                          <Object-id_id>55148</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>UBR7</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
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                        <Object-id>
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          <Gene-commentary_create-date>
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                <Date-std>
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            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_day>3</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
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        </Gene-commentary>
        <Gene-commentary>
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              <Pub_pmid>
                <PubMedId>26618866</PubMedId>
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            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>17110338</PubMedId>
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            </Pub>
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                <Dbtag>
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              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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                        <Object-id>
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                      </Dbtag_tag>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
                          <Object-id_id>1080</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>CFTR</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
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                <Date-std>
                  <Date-std_year>2018</Date-std_year>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
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            <Pub>
              <Pub_pmid>
                <PubMedId>28514442</PubMedId>
              </Pub_pmid>
            </Pub>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
                          <Object-id_id>51162</Object-id_id>
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                      </Dbtag_tag>
                    </Dbtag>
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                  <Other-source_anchor>EGFL7</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2017</Date-std_year>
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                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>26</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
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              <Pub_pmid>
                <PubMedId>28514442</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
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                <Dbtag>
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                    <Object-id>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5806</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PTX3</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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              </Gene-commentary_source>
            </Gene-commentary>
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          <Gene-commentary_create-date>
            <Date>
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                <Date-std>
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                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>26</Date-std_minute>
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                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>47</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
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                <PubMedId>25241761</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>9344465</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
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                <Dbtag>
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                  </Dbtag_tag>
                </Dbtag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
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                    <Dbtag>
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                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
                          <Object-id_id>4313</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MMP2</Other-source_anchor>
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                <Other-source>
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                    <Dbtag>
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                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
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                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
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          <Gene-commentary_create-date>
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                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>58</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
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              <Pub_pmid>
                <PubMedId>25241761</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>10714547</PubMedId>
              </Pub_pmid>
            </Pub>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                  </Dbtag_tag>
                </Dbtag>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
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                <Other-source>
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                    <Dbtag>
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                      <Dbtag_tag>
                        <Object-id>
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                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
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            <Date>
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                <Date-std>
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                </Date-std>
              </Date_std>
            </Date>
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            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_day>5</Date-std_day>
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                </Date-std>
              </Date_std>
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        </Gene-commentary>
        <Gene-commentary>
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                <Dbtag>
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                  </Dbtag_tag>
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              <Other-source_anchor>BioGRID</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
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                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
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                      </Dbtag_tag>
                    </Dbtag>
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              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
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              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
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                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>IL1B</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>109769</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2016</Date-std_year>
                  <Date-std_month>3</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>58</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-Western; Co-localization</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>25241761</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>1702714</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>354</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>KLK3</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106850</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2016</Date-std_year>
                  <Date-std_month>3</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>58</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>25281560</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>29079</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MED4</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>118849</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2016</Date-std_year>
                  <Date-std_month>2</Date-std_month>
                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>23</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Synthetic Lethality</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>19490893</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>KRAS</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110043</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2015</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>10</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>26465331</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3316</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>HSPB2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>109548</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2015</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>11</Date-std_hour>
                  <Date-std_minute>10</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>23602568</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5597</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MAPK6</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111583</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>49</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>23602568</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1022</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CDK7</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>107457</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>49</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>23602568</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>728642</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CDK11A</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>609064</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>49</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
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            <Pub>
              <Pub_pmid>
                <PubMedId>23602568</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>204851</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>HIPK1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>128490</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>49</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>22268729</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>26270</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>FBXO6</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>117654</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>49</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-MS</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>20085233</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>8626</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TP63</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>4</Date-std_month>
                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>36</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21988832</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7052</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TGM2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>36</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3437</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>IFIT3</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
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                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
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                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3337</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>DNAJB1</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>109569</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
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                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
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                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
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                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2639</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>GCDH</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>108909</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2193</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>FARSA</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>108487</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2026</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ENO2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>108340</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1995</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ELAVL3</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>108310</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1562</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CYP2C18</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>107938</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1558</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CYP2C8</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>107936</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>476</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ATP1A1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106966</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>351</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>APP</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106848</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-Western; Reconstituted Complex; Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>9831625</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>348</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>APOE</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106845</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>60</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ACTB</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106575</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>A2M</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>140545</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RNF32</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>126622</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>126074</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>SWSAP1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>125954</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>126003</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TRAPPC5</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>125945</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>115704</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>EVI5L</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>125449</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>112398</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>EGLN2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>125184</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>93185</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>IGSF8</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>125011</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>84106</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PRAM1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>123894</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>64223</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MLST8</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>122113</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>57559</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>STAMBPL1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>121614</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>56729</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RETN</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>121192</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>54850</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>FBXL12</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>120200</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>51295</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ECSIT</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>119446</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>51024</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>FIS1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>119230</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>51013</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>EXOSC1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>119220</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>24138</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>IFIT5</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>117289</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>23154</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NCDN</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>116768</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>22983</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MAST1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>116632</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>22976</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PAXIP1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>116625</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>11140</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CDC37</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>116312</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10724</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>OGA</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>115948</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10376</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TUBA1B</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10053</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>AP1M2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>115364</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LONP1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114762</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
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              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7372</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>UMPS</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113218</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7301</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TYRO3</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113152</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7001</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PRDX2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>112860</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6468</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>FBXW4</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>112364</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6009</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RHEB</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111941</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5886</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RAD23A</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111823</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5864</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RAB3A</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111802</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21163940</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4846</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NOS3</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110909</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2013</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>16289162</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4653</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MYOC</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110736</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>11</Date-std_month>
                  <Date-std_day>4</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>21</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>15862967</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6462</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>SHBG</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>112359</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>10</Date-std_month>
                  <Date-std_day>7</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>20</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>8848</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TSC22D1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114374</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>8764</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TNFRSF14</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114298</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7353</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>UFD1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113200</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7276</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TTR</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113127</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7083</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TK1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>112938</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7050</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TGIF1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>112908</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6606</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>SMN1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>112490</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5908</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RAP1B</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111843</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3163</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>HMOX2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>109406</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3014</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>H2AX</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>109268</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>18624398</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2885</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>GRB2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>109142</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>18624398</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2669</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>GEM</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>108937</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1026</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CDKN1A</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>107460</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>18624398</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>998</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CDC42</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>107433</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>310</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ANXA7</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106807</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>23176</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>SEPTIN8</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>116788</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>11102</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>RPP14</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>116283</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>11051</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NUDT21</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>116237</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10944</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>C11orf58</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>116144</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Two-hybrid</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>21900206</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10263</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CDK2AP2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>115555</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2012</Date-std_year>
                  <Date-std_month>1</Date-std_month>
                  <Date-std_day>8</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>22</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>16169070</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>10944</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>C11orf58</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>74735316</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>O00193</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>15231748</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>55729</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ATF7IP</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_anchor>Activating transcription factor 7 interacting protein</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>10681572</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4803</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NGF</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>90110037</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01138</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>11435418</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
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                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
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                        <Object-id>
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                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3931</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LCAT</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>125993</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P04180</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>10373500</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>9510</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ADAMTS1</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>124053460</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Q9UHI8</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>11162584</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>8728</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ADAM19</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>302393821</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Q9H013</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>10681572</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>7045</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>TGFBI</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>2498193</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Q15582</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>16289162</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4653</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MYOC</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3024209</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Q99972</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>10681572</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5155</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PDGFB</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>129724</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01127</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>15862967</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6462</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>SHBG</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>134907</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P04278</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
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        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>7533162</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>7519849</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>1697852</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>259</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>AMBP</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>122801</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02760</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>8583572</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>354</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>KLK3</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>130989</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P07288</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>10681572</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5154</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PDGFA</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>129719</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P04085</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>11023837</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5047</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PAEP</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>130701</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P09466</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>9724081</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3952</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LEP</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>730218</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P41159</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>2467766</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4069</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LYZ</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>48428995</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P61626</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>9428387</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3817</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>KLK2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>125174</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P20151</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>9714181</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>2466831</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
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          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
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                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3553</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>IL1B</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>62906858</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01584</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>12194978</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3309</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>HSPA5</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>14916999</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P11021</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>6191979</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>6153632</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>80233</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1990</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CELA1</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>62298049</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Q9UNI1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>10714547</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3586</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>IL10</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>124292</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P22301</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>9344465</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4313</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>MMP2</Other-source_anchor>
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                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>116856</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P08253</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>12631277</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1510</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CTSE</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1375381478</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P14091</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>2476070</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1508</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CTSB</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>68067549</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P07858</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>15226301</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>309</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ANXA6</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>113962</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P08133</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>10731476</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>567</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>B2M</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>48428791</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P61769</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>12194978</PubMedId>
              </Pub_pmid>
            </Pub>
            <Pub>
              <Pub_pmid>
                <PubMedId>10652313</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4035</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LRP1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>317373384</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Q07954</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>9831625</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>HPRD</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_str>00072</Object-id_str>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>HPRD</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>308153640</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P01023</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="peptide">8</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>348</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>APOE</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Protein</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114039</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>P02649</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>28</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2009</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>17</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>31</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>10681572</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4803</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>NGF</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110869</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2008</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>23</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>6</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-crystal Structure</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>10652313</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>4035</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LRP1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110215</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2008</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>23</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>6</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-Western; Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>11435418</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3931</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LCAT</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110123</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2008</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>23</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>6</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>10714547</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3565</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>IL4</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>109779</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2008</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>23</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>6</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>12194978</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3309</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>HSPA5</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>109541</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2008</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>23</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>6</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>10731476</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>567</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>B2M</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>107044</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2008</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>23</Date-std_day>
                  <Date-std_hour>9</Date-std_hour>
                  <Date-std_minute>6</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Affinity Capture-Western</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>10373500</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>9510</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>ADAMTS1</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>114888</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2008</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>8</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>34</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Co-purification; Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>11023837</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>5047</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>PAEP</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>111084</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2008</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>8</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>9724081</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>3952</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>LEP</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>110143</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2008</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>8</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>8662763</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>1361</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>CPB2</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>107753</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2008</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>6</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>8</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>12</Date-std_hour>
                  <Date-std_minute>33</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>Reconstituted Complex</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>14687906</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BioGRID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>106524</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BioGRID</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>106524</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>26085</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>KLK13</Other-source_anchor>
                </Other-source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>BioGRID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>117538</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2007</Date-std_year>
                  <Date-std_month>12</Date-std_month>
                  <Date-std_day>9</Date-std_day>
                  <Date-std_hour>10</Date-std_hour>
                  <Date-std_minute>4</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2018</Date-std_year>
                  <Date-std_month>8</Date-std_month>
                  <Date-std_day>5</Date-std_day>
                  <Date-std_hour>15</Date-std_hour>
                  <Date-std_minute>48</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="generif">18</Gene-commentary_type>
          <Gene-commentary_text>An unspecified isoform of STAT3 binds APRE.</Gene-commentary_text>
          <Gene-commentary_refs>
            <Pub>
              <Pub_pmid>
                <PubMedId>15950906</PubMedId>
              </Pub_pmid>
            </Pub>
          </Gene-commentary_refs>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>BIND</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>300537</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>BIND</Other-source_anchor>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="genomic">1</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>Nucleotide</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>24760</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>Z11711.1</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_source>
                <Other-source>
                  <Other-source_src>
                    <Dbtag>
                      <Dbtag_db>GeneID</Dbtag_db>
                      <Dbtag_tag>
                        <Object-id>
                          <Object-id_id>6774</Object-id_id>
                        </Object-id>
                      </Dbtag_tag>
                    </Dbtag>
                  </Other-source_src>
                  <Other-source_anchor>STAT3</Other-source_anchor>
                </Other-source>
              </Gene-commentary_source>
            </Gene-commentary>
          </Gene-commentary_comment>
          <Gene-commentary_create-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2005</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>29</Date-std_day>
                  <Date-std_hour>18</Date-std_hour>
                  <Date-std_minute>39</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_create-date>
          <Gene-commentary_update-date>
            <Date>
              <Date_std>
                <Date-std>
                  <Date-std_year>2005</Date-std_year>
                  <Date-std_month>7</Date-std_month>
                  <Date-std_day>29</Date-std_day>
                  <Date-std_hour>18</Date-std_hour>
                  <Date-std_minute>44</Date-std_minute>
                  <Date-std_second>0</Date-std_second>
                </Date-std>
              </Date_std>
            </Date>
          </Gene-commentary_update-date>
        </Gene-commentary>
      </Gene-commentary_comment>
    </Gene-commentary>
    <Gene-commentary>
      <Gene-commentary_type value="comment">254</Gene-commentary_type>
      <Gene-commentary_heading>Markers (Sequence Tagged Sites/STS)</Gene-commentary_heading>
      <Gene-commentary_comment>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>46849</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>RH11157</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>RH44108</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>stSG1290R</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>54816</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>SGC33440</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>EST131471</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>RH52636</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>SHGC-33440</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>WIAF-113</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>137000</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>G59851</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>SHGC-130452</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>40245</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>SGC31674</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>EST130345</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>RH52474</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>WI-219</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>147540</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>D12S1395E</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>GDB:189155</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>155252</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>GDB:181517</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>75646</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>RH46356</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>stSG22401</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>151442</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>D12S1160E</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>GDB:446067</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>95143</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>G44356</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>WIAF-1430-STS</Gene-commentary_text>
            </Gene-commentary>
          </Gene-commentary_comment>
        </Gene-commentary>
        <Gene-commentary>
          <Gene-commentary_type value="comment">254</Gene-commentary_type>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>UniSTS</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>25036</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_anchor>RH1601</Other-source_anchor>
              <Other-source_post-text>(e-PCR)</Other-source_post-text>
            </Other-source>
          </Gene-commentary_source>
          <Gene-commentary_comment>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
              <Gene-commentary_text>RH44109</Gene-commentary_text>
            </Gene-commentary>
            <Gene-commentary>
              <Gene-commentary_type value="other">255</Gene-commentary_type>
              <Gene-commentary_label>Alternate name</Gene-commentary_label>
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                                <Seq-id>
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        <Gene-commentary>
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            <Gene-commentary>
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            <Gene-commentary>
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                              <Seq-interval_id>
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            <Gene-commentary>
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                              <Seq-interval_strand>
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                              <Seq-interval_id>
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    <Gene-commentary>
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        <Gene-commentary>
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        <Gene-commentary>
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          <Gene-commentary_label>Category</Gene-commentary_label>
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    <Gene-commentary>
      <Gene-commentary_type value="gene-group">23</Gene-commentary_type>
      <Gene-commentary_heading>Orthologs from Annotation Pipeline</Gene-commentary_heading>
      <Gene-commentary_comment>
        <Gene-commentary>
          <Gene-commentary_type value="gene-group">23</Gene-commentary_type>
          <Gene-commentary_label>Primary</Gene-commentary_label>
          <Gene-commentary_source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>GeneID</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>2</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
              <Other-source_pre-text>A2M</Other-source_pre-text>
              <Other-source_anchor>human</Other-source_anchor>
            </Other-source>
            <Other-source>
              <Other-source_src>
                <Dbtag>
                  <Dbtag_db>taxon</Dbtag_db>
                  <Dbtag_tag>
                    <Object-id>
                      <Object-id_id>9606</Object-id_id>
                    </Object-id>
                  </Dbtag_tag>
                </Dbtag>
              </Other-source_src>
            </Other-source>
          </Gene-commentary_source>
        </Gene-commentary>
      </Gene-commentary_comment>
    </Gene-commentary>
  </Entrezgene_comments>
  <Entrezgene_unique-keys>
    <Dbtag>
      <Dbtag_db>HGNC</Dbtag_db>
      <Dbtag_tag>
        <Object-id>
          <Object-id_str>HGNC:7</Object-id_str>
        </Object-id>
      </Dbtag_tag>
    </Dbtag>
    <Dbtag>
      <Dbtag_db>LocusID</Dbtag_db>
      <Dbtag_tag>
        <Object-id>
          <Object-id_id>2</Object-id_id>
        </Object-id>
      </Dbtag_tag>
    </Dbtag>
    <Dbtag>
      <Dbtag_db>MIM</Dbtag_db>
      <Dbtag_tag>
        <Object-id>
          <Object-id_id>103950</Object-id_id>
        </Object-id>
      </Dbtag_tag>
    </Dbtag>
  </Entrezgene_unique-keys>
  <Entrezgene_xtra-index-terms>
    <Entrezgene_xtra-index-terms_E>LOC2</Entrezgene_xtra-index-terms_E>
  </Entrezgene_xtra-index-terms>
</Entrezgene>
</Entrezgene-Set>