Seq-entry ::= set {
  level 1,
  class nuc-prot,
  descr {
    source {
      genome genomic,
      org {
        taxname "Homo sapiens",
        common "human",
        db {
          {
            db "taxon",
            tag id 9606
          }
        },
        orgname {
          name binomial {
            genus "Homo",
            species "sapiens"
          },
          attrib "specified",
          lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
 Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
 Catarrhini; Hominidae; Homo",
          gcode 1,
          mgcode 2,
          div "PRI"
        }
      },
      subtype {
        {
          subtype chromosome,
          name "5"
        },
        {
          subtype map,
          name "5q33.3"
        }
      }
    },
    pub {
      pub {
        pmid 28635957,
        article {
          title {
            name "ITK signalling via the Ras/IRF4 pathway regulates the
 development and function of Tr1 cells."
          },
          authors {
            names std {
              {
                name ml "Huang W",
                affil str "Center for Clinical Immunology, The Third
 Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630,
 China.; Department of Microbiology and Immunology, Cornell University,
 Ithaca, New York 14853, USA."
              },
              {
                name ml "Solouki S",
                affil str "Department of Microbiology and Immunology, Cornell
 University, Ithaca, New York 14853, USA."
              },
              {
                name ml "Koylass N",
                affil str "Department of Microbiology and Immunology, Cornell
 University, Ithaca, New York 14853, USA."
              },
              {
                name ml "Zheng SG",
                affil str "Center for Clinical Immunology, The Third
 Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630,
 China.; Department of Medicine, Milton S. Hershey Medical Center,
 Pennsylvania State University, Hershey, Pennsylvania 17033, USA."
              },
              {
                name ml "August A",
                affil str "Department of Microbiology and Immunology, Cornell
 University, Ithaca, New York 14853, USA."
              }
            }
          },
          from journal {
            title {
              iso-jta "Nat Commun",
              ml-jta "Nat Commun",
              issn "2041-1723",
              name "Nature communications"
            },
            imp {
              date std {
                year 2017,
                month 6,
                day 21
              },
              volume "8",
              pages "15871",
              language "eng",
              pubstatus epublish,
              history {
                {
                  pubstatus received,
                  date std {
                    year 2016,
                    month 6,
                    day 29
                  }
                },
                {
                  pubstatus accepted,
                  date std {
                    year 2017,
                    month 5,
                    day 5
                  }
                },
                {
                  pubstatus other,
                  date std {
                    year 2017,
                    month 6,
                    day 22,
                    hour 6,
                    minute 0
                  }
                },
                {
                  pubstatus pubmed,
                  date std {
                    year 2017,
                    month 6,
                    day 22,
                    hour 6,
                    minute 0
                  }
                },
                {
                  pubstatus medline,
                  date std {
                    year 2019,
                    month 1,
                    day 15,
                    hour 6,
                    minute 0
                  }
                }
              }
            }
          },
          ids {
            pubmed 28635957,
            pii "ncomms15871",
            doi "10.1038/ncomms15871",
            other {
              db "pmc",
              tag str "PMC5482062"
            },
            other {
              db "ELocationID doi",
              tag str "10.1038/ncomms15871"
            }
          }
        }
      },
      comment "GeneRIF: ITK signalling through the Ras/IRF4 pathway is
 required for functional development of type 1 regulatory T cells."
    },
    pub {
      pub {
        pmid 28213500,
        article {
          title {
            name "Inducible T Cell Kinase Regulates the Acquisition of
 Cytolytic Capacity and Degranulation in CD8(+) CTLs."
          },
          authors {
            names std {
              {
                name ml "Kapnick SM",
                affil str "National Human Genome Research Institute, Bethesda,
 MD 20892; and."
              },
              {
                name ml "Stinchcombe JC",
                affil str "Cambridge Institute for Medical Research,
 University of Cambridge, Cambridge CB2 0XY, United Kingdom."
              },
              {
                name ml "Griffiths GM",
                affil str "Cambridge Institute for Medical Research,
 University of Cambridge, Cambridge CB2 0XY, United Kingdom."
              },
              {
                name ml "Schwartzberg PL",
                affil str "National Human Genome Research Institute, Bethesda,
 MD 20892; and pams@nhgri.nih.gov."
              }
            }
          },
          from journal {
            title {
              iso-jta "J. Immunol.",
              ml-jta "J Immunol",
              issn "1550-6606",
              name "Journal of immunology (Baltimore, Md. : 1950)"
            },
            imp {
              date std {
                year 2017,
                month 4,
                day 1
              },
              volume "198",
              issue "7",
              pages "2699-2711",
              language "eng",
              pubstatus ppublish,
              history {
                {
                  pubstatus received,
                  date std {
                    year 2016,
                    month 7,
                    day 11
                  }
                },
                {
                  pubstatus accepted,
                  date std {
                    year 2017,
                    month 1,
                    day 19
                  }
                },
                {
                  pubstatus pubmed,
                  date std {
                    year 2017,
                    month 2,
                    day 19,
                    hour 6,
                    minute 0
                  }
                },
                {
                  pubstatus medline,
                  date std {
                    year 2017,
                    month 8,
                    day 16,
                    hour 6,
                    minute 0
                  }
                },
                {
                  pubstatus other,
                  date std {
                    year 2017,
                    month 2,
                    day 19,
                    hour 6,
                    minute 0
                  }
                }
              }
            }
          },
          ids {
            pubmed 28213500,
            pii "jimmunol.1601202",
            doi "10.4049/jimmunol.1601202",
            other {
              db "pmc",
              tag str "PMC5360469"
            },
            other {
              db "mid",
              tag str "NIHMS847215"
            },
            other {
              db "ELocationID doi",
              tag str "10.4049/jimmunol.1601202"
            }
          }
        }
      },
      comment "GeneRIF: Our results provide new insight into the effect of ITK
 and suboptimal T-cell receptor signaling on CD8(+) T cell function, and how
 these may contribute to phenotypes associated with ITK deficiency"
    },
    pub {
      pub {
        pmid 27780854,
        article {
          title {
            name "T-cell Receptor Signaling Activates an ITK/NF-kappaB/GATA-3
 axis in T-cell Lymphomas Facilitating Resistance to Chemotherapy."
          },
          authors {
            names std {
              {
                name ml "Wang T",
                affil str "Department of Internal Medicine, Division of
 Hematology and Oncology, University of Michigan, Ann Arbor, Michigan."
              },
              {
                name ml "Lu Y",
                affil str "Department of Internal Medicine, Division of
 Hematology and Oncology, University of Michigan, Ann Arbor, Michigan."
              },
              {
                name ml "Polk A",
                affil str "Department of Internal Medicine, Division of
 Hematology and Oncology, University of Michigan, Ann Arbor, Michigan."
              },
              {
                name ml "Chowdhury P",
                affil str "Department of Internal Medicine, Division of
 Hematology and Oncology, University of Michigan, Ann Arbor, Michigan."
              },
              {
                name ml "Murga-Zamalloa C",
                affil str "Department of Internal Medicine, Division of
 Hematology and Oncology, University of Michigan, Ann Arbor, Michigan.;
 Department of Pathology, University of Michigan, Ann Arbor, Michigan."
              },
              {
                name ml "Fujiwara H",
                affil str "Department of Hematology, Clinical Immunology and
 Infectious Disease, Graduate School of Medicine, Ehime University, Toon,
 Ehime, Japan."
              },
              {
                name ml "Suemori K",
                affil str "Department of Hematology, Clinical Immunology and
 Infectious Disease, Graduate School of Medicine, Ehime University, Toon,
 Ehime, Japan."
              },
              {
                name ml "Beyersdorf N",
                affil str "Institute for Virology and Immunobiology,
 University of Wurzburg, Wurzburg, Germany."
              },
              {
                name ml "Hristov AC",
                affil str "Department of Pathology, University of Michigan,
 Ann Arbor, Michigan.; Department of Dermatology, University of Michigan, Ann
 Arbor, Michigan."
              },
              {
                name ml "Lim MS",
                affil str "Department of Pathology and Laboratory Medicine,
 University of Pennsylvania, Philadelphia, Pennsylvania."
              },
              {
                name ml "Bailey NG",
                affil str "Department of Pathology, University of Pittsburgh,
 Pittsburgh, Pennsylvania."
              },
              {
                name ml "Wilcox RA",
                affil str "Department of Internal Medicine, Division of
 Hematology and Oncology, University of Michigan, Ann Arbor, Michigan.
 rywilcox@med.umich.edu."
              }
            }
          },
          from journal {
            title {
              iso-jta "Clin. Cancer Res.",
              ml-jta "Clin Cancer Res",
              issn "1078-0432",
              name "Clinical cancer research : an official journal of the
 American Association for Cancer Research"
            },
            imp {
              date std {
                year 2017,
                month 5,
                day 15
              },
              volume "23",
              issue "10",
              pages "2506-2515",
              language "eng",
              retract {
                type in-error,
                exp "Clin Cancer Res. 2017 Oct 1;23 (19):5995. PMID: 28972087"
              },
              pubstatus ppublish,
              history {
                {
                  pubstatus received,
                  date std {
                    year 2016,
                    month 8,
                    day 12
                  }
                },
                {
                  pubstatus revised,
                  date std {
                    year 2016,
                    month 9,
                    day 16
                  }
                },
                {
                  pubstatus accepted,
                  date std {
                    year 2016,
                    month 10,
                    day 11
                  }
                },
                {
                  pubstatus pubmed,
                  date std {
                    year 2016,
                    month 11,
                    day 1,
                    hour 6,
                    minute 0
                  }
                },
                {
                  pubstatus medline,
                  date std {
                    year 2018,
                    month 2,
                    day 23,
                    hour 6,
                    minute 0
                  }
                },
                {
                  pubstatus other,
                  date std {
                    year 2016,
                    month 11,
                    day 1,
                    hour 6,
                    minute 0
                  }
                }
              }
            }
          },
          ids {
            pubmed 27780854,
            pii "1078-0432.CCR-16-1996",
            doi "10.1158/1078-0432.CCR-16-1996",
            other {
              db "pmc",
              tag str "PMC5405012"
            },
            other {
              db "mid",
              tag str "NIHMS827084"
            },
            other {
              db "ELocationID doi",
              tag str "10.1158/1078-0432.CCR-16-1996"
            }
          }
        }
      },
      comment "GeneRIF: These observations have significant therapeutic
 implications, as pharmacologic inhibition of ITK prevented the activation of
 this signaling axis and overcame chemotherapy resistance."
    },
    pub {
      pub {
        pmid 27729219,
        article {
          title {
            name "Interleukin-2-inducible T-cell kinase expression and
 relation to disease severity in systemic lupus erythematosus."
          },
          authors {
            names std {
              {
                name ml "Xu WD",
                affil str "Department of Rheumatology and Immunology, West
 China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, Sichuan 610041,
 PR China."
              },
              {
                name ml "Su LC",
                affil str "Department of Rheumatology and Immunology, West
 China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, Sichuan 610041,
 PR China."
              },
              {
                name ml "Xie QB",
                affil str "Department of Rheumatology and Immunology, West
 China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, Sichuan 610041,
 PR China."
              },
              {
                name ml "Zhao Y",
                affil str "Department of Rheumatology and Immunology, West
 China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, Sichuan 610041,
 PR China."
              },
              {
                name ml "Liu Y",
                affil str "Department of Rheumatology and Immunology, West
 China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, Sichuan 610041,
 PR China. Electronic address: yi2006liu@163.com."
              }
            }
          },
          from journal {
            title {
              iso-jta "Clin. Chim. Acta",
              ml-jta "Clin Chim Acta",
              issn "1873-3492",
              name "Clinica chimica acta; international journal of clinical
 chemistry"
            },
            imp {
              date std {
                year 2016,
                month 12,
                day 1
              },
              volume "463",
              pages "11-17",
              language "eng",
              pubstatus ppublish,
              history {
                {
                  pubstatus received,
                  date std {
                    year 2016,
                    month 7,
                    day 12
                  }
                },
                {
                  pubstatus revised,
                  date std {
                    year 2016,
                    month 9,
                    day 24
                  }
                },
                {
                  pubstatus accepted,
                  date std {
                    year 2016,
                    month 10,
                    day 7
                  }
                },
                {
                  pubstatus pubmed,
                  date std {
                    year 2016,
                    month 11,
                    day 5,
                    hour 6,
                    minute 0
                  }
                },
                {
                  pubstatus medline,
                  date std {
                    year 2017,
                    month 2,
                    day 14,
                    hour 6,
                    minute 0
                  }
                },
                {
                  pubstatus other,
                  date std {
                    year 2016,
                    month 11,
                    day 6,
                    hour 6,
                    minute 0
                  }
                }
              }
            }
          },
          ids {
            pubmed 27729219,
            pii "S0009-8981(16)30407-7",
            doi "10.1016/j.cca.2016.10.010",
            other {
              db "ELocationID pii",
              tag str "S0009-8981(16)30407-7"
            },
            other {
              db "ELocationID doi",
              tag str "10.1016/j.cca.2016.10.010"
            }
          }
        }
      },
      comment "GeneRIF: The data indicate that increased ITK expression could
 act as a disease activity marker and as a risk factor for involvement in SLE,
 but it still needs further study to confirm."
    },
    pub {
      pub {
        pmid 25934889,
        article {
          title {
            name "IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in
 Melanoma."
          },
          authors {
            names std {
              {
                name ml "Carson CC",
                affil str "Department of Dermatology, The University of North
 Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Moschos SJ",
                affil str "Department of Medicine, The University of North
 Carolina, Chapel Hill, North Carolina. Lineberger Comprehensive Cancer
 Center, The University of North Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Edmiston SN",
                affil str "Lineberger Comprehensive Cancer Center, The
 University of North Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Darr DB",
                affil str "Lineberger Comprehensive Cancer Center, The
 University of North Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Nikolaishvili-Feinberg N",
                affil str "Lineberger Comprehensive Cancer Center, The
 University of North Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Groben PA",
                affil str "Department of Pathology and Laboratory Medicine,
 The University of North Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Zhou X",
                affil str "Department of Biostatistics, The University of
 North Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Kuan PF",
                affil str "Lineberger Comprehensive Cancer Center, The
 University of North Carolina, Chapel Hill, North Carolina. Department of
 Biostatistics, The University of North Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Pandey S",
                affil str "Department of Dermatology, The University of North
 Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Chan KT",
                affil str "Lineberger Comprehensive Cancer Center, The
 University of North Carolina, Chapel Hill, North Carolina. Department of Cell
 Biology and Physiology, The University of North Carolina, Chapel Hill, North
 Carolina."
              },
              {
                name ml "Jordan JL",
                affil str "Lineberger Comprehensive Cancer Center, The
 University of North Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Hao H",
                affil str "Department of Dermatology, The University of North
 Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Frank JS",
                affil str "Department of Surgery, The University of North
 Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Hopkinson DA",
                affil str "Department of Dermatology, The University of North
 Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Gibbs DC",
                affil str "Department of Dermatology, The University of North
 Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Alldredge VD",
                affil str "Department of Dermatology, The University of North
 Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Parrish E",
                affil str "Lineberger Comprehensive Cancer Center, The
 University of North Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Hanna SC",
                affil str "Lineberger Comprehensive Cancer Center, The
 University of North Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Berkowitz P",
                affil str "Department of Dermatology, The University of North
 Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Rubenstein DS",
                affil str "Department of Dermatology, The University of North
 Carolina, Chapel Hill, North Carolina. Lineberger Comprehensive Cancer
 Center, The University of North Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Miller CR",
                affil str "Lineberger Comprehensive Cancer Center, The
 University of North Carolina, Chapel Hill, North Carolina. Department of
 Pathology and Laboratory Medicine, The University of North Carolina, Chapel
 Hill, North Carolina. Department of Neurology, The University of North
 Carolina, Chapel Hill, North Carolina. Neuroscience Center, The University of
 North Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Bear JE",
                affil str "Lineberger Comprehensive Cancer Center, The
 University of North Carolina, Chapel Hill, North Carolina. Department of Cell
 Biology and Physiology, The University of North Carolina, Chapel Hill, North
 Carolina."
              },
              {
                name ml "Ollila DW",
                affil str "Lineberger Comprehensive Cancer Center, The
 University of North Carolina, Chapel Hill, North Carolina. Department of
 Surgery, The University of North Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Sharpless NE",
                affil str "Department of Medicine, The University of North
 Carolina, Chapel Hill, North Carolina. Lineberger Comprehensive Cancer
 Center, The University of North Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Conway K",
                affil str "Lineberger Comprehensive Cancer Center, The
 University of North Carolina, Chapel Hill, North Carolina. Department of
 Epidemiology, The University of North Carolina, Chapel Hill, North Carolina."
              },
              {
                name ml "Thomas NE",
                affil str "Department of Dermatology, The University of North
 Carolina, Chapel Hill, North Carolina. Lineberger Comprehensive Cancer
 Center, The University of North Carolina, Chapel Hill, North Carolina.
 nthomas@med.unc.edu."
              }
            }
          },
          from journal {
            title {
              iso-jta "Clin. Cancer Res.",
              ml-jta "Clin Cancer Res",
              issn "1078-0432",
              name "Clinical cancer research : an official journal of the
 American Association for Cancer Research"
            },
            imp {
              date std {
                year 2015,
                month 5,
                day 1
              },
              volume "21",
              issue "9",
              pages "2167-2176",
              language "eng",
              pubstatus ppublish,
              history {
                {
                  pubstatus other,
                  date std {
                    year 2015,
                    month 5,
                    day 3,
                    hour 6,
                    minute 0
                  }
                },
                {
                  pubstatus pubmed,
                  date std {
                    year 2015,
                    month 5,
                    day 3,
                    hour 6,
                    minute 0
                  }
                },
                {
                  pubstatus medline,
                  date std {
                    year 2016,
                    month 4,
                    day 1,
                    hour 6,
                    minute 0
                  }
                }
              }
            }
          },
          ids {
            pubmed 25934889,
            pii "21/9/2167",
            doi "10.1158/1078-0432.CCR-14-1826",
            other {
              db "pmc",
              tag str "PMC4418029"
            },
            other {
              db "mid",
              tag str "NIHMS661555"
            },
            other {
              db "ELocationID doi",
              tag str "10.1158/1078-0432.CCR-14-1826"
            }
          }
        }
      },
      comment "GeneRIF: We conclude that ITK, formerly considered an immune
 cell-specific protein, is aberrantly expressed in melanoma and promotes tumor
 development and progression"
    },
    pub {
      pub {
        pmid 8629002,
        article {
          title {
            name "Activation of BTK by a phosphorylation mechanism initiated
 by SRC family kinases."
          },
          authors {
            names std {
              {
                name ml "Rawlings DJ",
                affil str "Department of Microbiology and Molecular Genetics,
 University of California, Los Angeles 90095-1662, USA."
              },
              {
                name ml "Scharenberg AM"
              },
              {
                name ml "Park H"
              },
              {
                name ml "Wahl MI"
              },
              {
                name ml "Lin S"
              },
              {
                name ml "Kato RM"
              },
              {
                name ml "Fluckiger AC"
              },
              {
                name ml "Witte ON"
              },
              {
                name ml "Kinet JP"
              }
            }
          },
          from journal {
            title {
              iso-jta "Science",
              ml-jta "Science",
              issn "0036-8075",
              name "Science (New York, N.Y.)"
            },
            imp {
              date std {
                year 1996,
                month 2,
                day 9
              },
              volume "271",
              issue "5250",
              pages "822-825",
              language "eng",
              pubstatus ppublish,
              history {
                {
                  pubstatus pubmed,
                  date std {
                    year 1996,
                    month 2,
                    day 9
                  }
                },
                {
                  pubstatus medline,
                  date std {
                    year 1996,
                    month 2,
                    day 9,
                    hour 0,
                    minute 1
                  }
                },
                {
                  pubstatus other,
                  date std {
                    year 1996,
                    month 2,
                    day 9,
                    hour 0,
                    minute 0
                  }
                }
              }
            }
          },
          ids {
            pubmed 8629002,
            doi "10.1126/science.271.5250.822"
          }
        }
      }
    },
    pub {
      pub {
        pmid 8504851,
        article {
          title {
            name "A novel human tyrosine kinase gene inducible in T cells by
 interleukin 2."
          },
          authors {
            names std {
              {
                name ml "Tanaka N",
                affil str "Department of Microbiology, Tohoku University
 School of Medicine, Sendai, Japan."
              },
              {
                name ml "Asao H"
              },
              {
                name ml "Ohtani K"
              },
              {
                name ml "Nakamura M"
              },
              {
                name ml "Sugamura K"
              }
            }
          },
          from journal {
            title {
              iso-jta "FEBS Lett.",
              ml-jta "FEBS Lett",
              issn "0014-5793",
              name "FEBS letters"
            },
            imp {
              date std {
                year 1993,
                month 6,
                day 7
              },
              volume "324",
              issue "1",
              pages "1-5",
              language "eng",
              pubstatus ppublish,
              history {
                {
                  pubstatus pubmed,
                  date std {
                    year 1993,
                    month 6,
                    day 7
                  }
                },
                {
                  pubstatus medline,
                  date std {
                    year 1993,
                    month 6,
                    day 7,
                    hour 0,
                    minute 1
                  }
                },
                {
                  pubstatus other,
                  date std {
                    year 1993,
                    month 6,
                    day 7,
                    hour 0,
                    minute 0
                  }
                }
              }
            }
          },
          ids {
            pubmed 8504851,
            pii "0014-5793(93)81520-A",
            doi "10.1016/0014-5793(93)81520-a"
          }
        }
      }
    },
    pub {
      pub {
        pmid 8364206,
        article {
          title {
            name "Identification, cloning, and characterization of a novel
 human T-cell-specific tyrosine kinase located at the hematopoietin complex on
 chromosome 5q."
          },
          authors {
            names std {
              {
                name ml "Gibson S",
                affil str "Oncology Research Division, Toronto General
 Hospital, Ontario, Canada."
              },
              {
                name ml "Leung B"
              },
              {
                name ml "Squire JA"
              },
              {
                name ml "Hill M"
              },
              {
                name ml "Arima N"
              },
              {
                name ml "Goss P"
              },
              {
                name ml "Hogg D"
              },
              {
                name ml "Mills GB"
              }
            }
          },
          from journal {
            title {
              iso-jta "Blood",
              ml-jta "Blood",
              issn "0006-4971",
              name "Blood"
            },
            imp {
              date std {
                year 1993,
                month 9,
                day 1
              },
              volume "82",
              issue "5",
              pages "1561-1572",
              language "eng",
              pubstatus ppublish,
              history {
                {
                  pubstatus pubmed,
                  date std {
                    year 1993,
                    month 9,
                    day 1
                  }
                },
                {
                  pubstatus medline,
                  date std {
                    year 1993,
                    month 9,
                    day 1,
                    hour 0,
                    minute 1
                  }
                },
                {
                  pubstatus other,
                  date std {
                    year 1993,
                    month 9,
                    day 1,
                    hour 0,
                    minute 0
                  }
                }
              }
            }
          },
          ids {
            pubmed 8364206
          }
        }
      }
    },
    pub {
      pub {
        pmid 7829087,
        article {
          title {
            name "Mapping of the gene for the tyrosine kinase Itk to a region
 of conserved synteny between mouse chromosome 11 and human chromosome 5q."
          },
          authors {
            names std {
              {
                name ml "Janis EM",
                affil str "Department of Molecular Biology and Genetics, Johns
 Hopkins University School of Medicine, Baltimore, Maryland 21205."
              },
              {
                name ml "Siliciano JD"
              },
              {
                name ml "Isaac DD"
              },
              {
                name ml "Griffin CA"
              },
              {
                name ml "Hawkins AL"
              },
              {
                name ml "Kozak CA"
              },
              {
                name ml "Desiderio S"
              }
            }
          },
          from journal {
            title {
              iso-jta "Genomics",
              ml-jta "Genomics",
              issn "0888-7543",
              name "Genomics"
            },
            imp {
              date std {
                year 1994,
                month 9,
                day 1
              },
              volume "23",
              issue "1",
              pages "269-271",
              language "eng",
              pubstatus ppublish,
              history {
                {
                  pubstatus pubmed,
                  date std {
                    year 1994,
                    month 9,
                    day 1
                  }
                },
                {
                  pubstatus medline,
                  date std {
                    year 1994,
                    month 9,
                    day 1,
                    hour 0,
                    minute 1
                  }
                },
                {
                  pubstatus other,
                  date std {
                    year 1994,
                    month 9,
                    day 1,
                    hour 0,
                    minute 0
                  }
                }
              }
            }
          },
          ids {
            pubmed 7829087,
            pii "S0888754384714923",
            doi "10.1006/geno.1994.1492"
          }
        }
      }
    },
    pub {
      pub {
        pmid 7567982,
        article {
          title {
            name "Activation of Tsk and Btk tyrosine kinases by G protein beta
 gamma subunits."
          },
          authors {
            names std {
              {
                name ml "Langhans-Rajasekaran SA",
                affil str "Department of Physiology, Cornell University
 Medical College, New York, NY 10021, USA."
              },
              {
                name ml "Wan Y"
              },
              {
                name ml "Huang XY"
              }
            }
          },
          from journal {
            title {
              iso-jta "Proc. Natl. Acad. Sci. U.S.A.",
              ml-jta "Proc Natl Acad Sci U S A",
              issn "0027-8424",
              name "Proceedings of the National Academy of Sciences of the
 United States of America"
            },
            imp {
              date std {
                year 1995,
                month 9,
                day 12
              },
              volume "92",
              issue "19",
              pages "8601-8605",
              language "eng",
              pubstatus ppublish,
              history {
                {
                  pubstatus pubmed,
                  date std {
                    year 1995,
                    month 9,
                    day 12
                  }
                },
                {
                  pubstatus medline,
                  date std {
                    year 1995,
                    month 9,
                    day 12,
                    hour 0,
                    minute 1
                  }
                },
                {
                  pubstatus other,
                  date std {
                    year 1995,
                    month 9,
                    day 12,
                    hour 0,
                    minute 0
                  }
                }
              }
            }
          },
          ids {
            pubmed 7567982,
            other {
              db "pmc",
              tag str "PMC41014"
            },
            doi "10.1073/pnas.92.19.8601"
          }
        }
      }
    },
    comment "~Summary: This gene encodes an intracellular tyrosine kinase
 expressed in T-cells. The protein contains both SH2 and SH3 domains which are
 often found in intracellular kinases. It is thought to play a role in T-cell
 proliferation and differentiation. [provided by RefSeq, Jul 2008]",
    comment "~Publication Note:  This RefSeq record includes a subset of the
 publications that are available for this gene. Please see the Gene record to
 access additional publications.",
    user {
      type str "RefSeqGene",
      data {
        {
          label str "Status",
          data str "Reference Standard"
        }
      }
    },
    user {
      type str "RefGeneTracking",
      data {
        {
          label str "Status",
          data str "Reviewed"
        },
        {
          label str "Assembly",
          data fields {
            {
              label id 0,
              data fields {
                {
                  label str "accession",
                  data str "D13720.1"
                }
              }
            }
          }
        },
        {
          label str "SelectGeneLocation",
          data fields {
            {
              label str "seq_id",
              data str "ref|NC_000005.10|"
            },
            {
              label str "from",
              data int 157180895
            },
            {
              label str "to",
              data int 157255184
            },
            {
              label str "strand",
              data str "+"
            }
          }
        }
      }
    },
    user {
      type str "StructuredComment",
      data {
        {
          label str "StructuredCommentPrefix",
          data str "##Evidence-Data-START##"
        },
        {
          label str "Transcript exon combination",
          data str "D13720.1, BC109077.2 [ECO:0000332]"
        },
        {
          label str "RNAseq introns",
          data str "single sample supports all introns SAMEA1965299,
 SAMEA1966682 [ECO:0000348]"
        },
        {
          label str "StructuredCommentSuffix",
          data str "##Evidence-Data-END##"
        }
      }
    },
    user {
      type str "StructuredComment",
      data {
        {
          label str "StructuredCommentPrefix",
          data str "##RefSeq-Attributes-START##"
        },
        {
          label str "RefSeq Select criteria",
          data str "based on conservation, expression, longest protein"
        },
        {
          label str "StructuredCommentSuffix",
          data str "##RefSeq-Attributes-END##"
        }
      }
    },
    update-date std {
      year 2019,
      month 9,
      day 24
    }
  },
  seq-set {
    seq {
      id {
        other {
          accession "NM_005546",
          version 3
        },
        gi 21614549
      },
      descr {
        title "Homo sapiens IL2 inducible T cell kinase (ITK), mRNA",
        molinfo {
          biomol mRNA,
          completeness has-right
        },
        genbank {
          keywords {
            "RefSeq Select"
          }
        },
        create-date std {
          year 1999,
          month 6,
          day 9
        }
      },
      inst {
        repr raw,
        mol rna,
        length 4366,
        seq-data ncbi2na 'E4F7F95401DFD7FAFB9C22B8E542B9145FD081E8D38107F35D7A
081274D080D504022081F757607F02D67DFEEF0502525E931FE08DB4EA082646782AB53E277560
D03BBE23EE00B84D24D5394730315BF4AEB93841C5D733BBF9D48DB88969267AB9E95F02080628
30C12FEB970334D70FDE8E8EA0BA2B9EF749E8827E4129EE54338D41420E7D020977D75C75E084
129851FEA05E0807BAD3E5F338714050E35D281D91E6990608B1E5E7A12F788F47AE88B5284A0E
A4E0A33B1424BCDEBA00375030DE805CE2EB10C22CD2588409E001F7FE844A4082897D3AC2A3D4
A1E4A04C45BB7BFD1429EFB0B8810D5ECC093CD13428040E10D7098C73BA7802CEEF63D4D5DF74
D0734504C3A28A5EB8761D6B352FEFFA8A480954BC492A788C6A03AB8D855D22747FEE4223E92E
A43FABEB937A9C7A7410A10AE9CD0053DA82A9CED208A1F4C8A29E0B0E3807774D501EB927B3AA
EE5E8929553797AEFE2F4E891A797B48F37191526A87FF9E488579EA4EEDE8EEEE2A4E9717A08A
4EED351221FA79480FBFAEA20050B4D0AEDE1FEA3842BDBDE8E34B114BD44A4503D5AE0BA93552
2BFDDFD2D9CC9242D63BBAD3FAEE78EEA0BFD2E0A40356CE0058241D22BAE82134B168FDAFB109
569E975111B7148F383479E808885208DA525F7521E79B41E9E03E4834A1FCB221E2C52946A792
35E0E8A0A33B5D3D4C893C827945254A15D48A497A5EE934B578B453A0924D785127A4B425127A
2AD251427A89E25204A2E3B7795F5DC977ED13BAE4405D05E127F48493DF91F7C90488884E2C21
523E73FF3EF3FF04E0DC0BF3AF52A1FFCFE1504112CD528CE8A42A810224E2DFFD42007AE2F0B0
8F22E2EE77BE7B8E7B49449F5E5B220E32249E7444A2968CF788249FCE2BFC48B39E717775F82A
24E98854FA3A3EAB812F4AD539FA24FAB378EDE452042205DE1AE8814EEB9082237CADDF7FCC50
9D37FCC509EE4AE1CE5D77DE44839F514935E2080E3C7DE00135FFF525DEA0D255577791CD635D
34122A493EEFAD0EF57E9890F807EFCA572AF890FF0AF88750B75C03DCA2203022DEFFE740534A
3A012D291E1EAB9F508A4E22E5C77A7E247DCCE42B833B1E272887D5E40377BD15EAF44D54E2B0
CF3CF54FF1030EC1E29FC009421379502E3A07202DC89EB3DC95037B78590C448F7F3D73D847A7
DC78038068F922A0C0C408E8094B020B4B32051C9832EF9DE912147BAF8E93A57507E8328FF5FF
5CF7B35F17EB4EF0E1FE8BCF4BC3857F0F7441414B4EF9F8253F32189F40907F008F7DEC82CE2F
7D7F0F34F507F49ECB7DF811F4E28A84F578CC2228EBBE43E9DFDC0D3B86FF87A7E23D23930FFC
3CC3CFB82E88974230077B4F48238FF1D27CD403CDDEFC7FF20FFB13CDFFA8D7C3C88E3F7A04F4
B7202004FA0F878DDEEBFAFC803D57B93ACF17FF42748F4DC35D07B13BB13DF45D7AE57356403A
9F5E5EBFF77DD13FFC0EB55EEFEC881D5F3122FFAF72FF3F6C8FF93FEC5FF8873B3F33FA348E4C
FCF0EC4B479CBBD00C00EF1030'H,
        hist {
          replaces {
            date std {
              year 2002,
              month 6,
              day 26
            },
            ids {
              gi 15718679
            }
          },
          replaced-by {
            date std {
              year 2019,
              month 9,
              day 27
            },
            ids {
              gi 1752318713
            }
          }
        }
      },
      annot {
        {
          data ftable {
            {
              data imp {
                key "regulatory"
              },
              location int {
                from 4348,
                to 4353,
                strand plus,
                id gi 21614549
              },
              qual {
                {
                  qual "regulatory_class",
                  val "polyA_signal_sequence"
                }
              }
            },
            {
              data imp {
                key "polyA_site"
              },
              location pnt {
                point 4365,
                strand plus,
                id gi 21614549
              },
              exp-ev experimental
            },
            {
              data gene {
                locus "ITK",
                desc "IL2 inducible T cell kinase",
                syn {
                  "EMT",
                  "LPFS1",
                  "LYK",
                  "PSCTK2"
                }
              },
              location int {
                from 0,
                to 4365,
                strand plus,
                id gi 21614549
              },
              dbxref {
                {
                  db "GeneID",
                  tag id 3702
                },
                {
                  db "HGNC",
                  tag str "HGNC:6171"
                },
                {
                  db "MIM",
                  tag id 186973
                }
              }
            }
          }
        }
      }
    },
    seq {
      id {
        other {
          accession "NP_005537",
          version 3
        },
        gi 15718680
      },
      descr {
        title "tyrosine-protein kinase ITK/TSK [Homo sapiens]",
        molinfo {
          biomol peptide
        },
        genbank {
          keywords {
            "RefSeq Select"
          }
        },
        create-date std {
          year 1999,
          month 6,
          day 9
        }
      },
      inst {
        repr raw,
        mol aa,
        length 620,
        seq-data ncbieaa "MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLK
GSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKYHPNFWMDGKW
RCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHW
WRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSEN
NPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELT
FVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGC
LSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKF
PVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKER
PEDRPAFSRLLRQLAEIAESGL",
        hist {
          replaces {
            date std {
              year 2001,
              month 9,
              day 21
            },
            ids {
              gi 7949058
            }
          }
        }
      },
      annot {
        {
          data ftable {
            {
              data prot {
                name {
                  "tyrosine-protein kinase ITK/TSK",
                  "tyrosine-protein kinase LYK",
                  "homolog of mouse T-cell itk/tsk",
                  "kinase EMT",
                  "T-cell-specific kinase",
                  "IL-2-inducible T-cell kinase",
                  "interleukin-2-inducible T-cell kinase"
                },
                ec {
                  "2.7.10.2"
                }
              },
              location int {
                from 0,
                to 619,
                id gi 15718680
              }
            },
            {
              data site phosphorylation,
              comment "Phosphotyrosine, by autocatalysis.
 {ECO:0000269|PubMed:12573241}; propagated from UniProtKB/Swiss-Prot (Q08881.1)",
              location pnt {
                point 179,
                id gi 15718680
              },
              exp-ev experimental
            },
            {
              data site phosphorylation,
              comment "Phosphotyrosine, by LCK. {ECO:0000244|PubMed:19690332};
 propagated from UniProtKB/Swiss-Prot (Q08881.1)",
              location pnt {
                point 511,
                id gi 15718680
              },
              exp-ev experimental
            },
            {
              data site phosphorylation,
              comment "Phosphoserine. {ECO:0000244|PubMed:19690332};
 propagated from UniProtKB/Swiss-Prot (Q08881.1)",
              location pnt {
                point 564,
                id gi 15718680
              },
              exp-ev experimental
            }
          }
        }
      }
    }
  },
  annot {
    {
      data ftable {
        {
          data cdregion {
            frame one,
            code {
              id 1
            }
          },
          product whole gi 15718680,
          location int {
            from 82,
            to 1944,
            strand plus,
            id gi 21614549
          },
          dbxref {
            {
              db "CCDS",
              tag str "CCDS4336.1"
            }
          }
        }
      }
    },
    {
      name "exons",
      data ftable {
        {
          data imp {
            key "exon"
          },
          location int {
            from 0,
            to 219,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 220,
            to 324,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 325,
            to 406,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 407,
            to 535,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 536,
            to 576,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 577,
            to 728,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 729,
            to 794,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 795,
            to 849,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 850,
            to 932,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 933,
            to 1066,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 1067,
            to 1141,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 1142,
            to 1313,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 1314,
            to 1530,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 1531,
            to 1595,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 1596,
            to 1714,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 1715,
            to 1872,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        },
        {
          data imp {
            key "exon"
          },
          location int {
            from 1873,
            to 4365,
            strand plus,
            id gi 21614549
          },
          qual {
            {
              qual "inference",
              val "alignment:Splign:2.1.0"
            }
          }
        }
      }
    }
  }
}

